Preprint Immunological and Antigenic Signatures Associated with Chronic Illnesses after COVID-19 Vaccination, 2025, Bhattacharjee et al

Nightsong

Nightsong

Senior Member (Voting Rights)
Abstract
COVID-19 vaccines have prevented millions of COVID-19 deaths. Yet, a small fraction of the population reports a chronic debilitating condition after COVID-19 vaccination, often referred to as post- vaccination syndrome (PVS). To explore potential pathobiological features associated with PVS, we conducted a decentralized, cross-sectional study involving 42 PVS participants and 22 healthy controls enrolled in the Yale LISTEN study.

Compared with controls, PVS participants exhibited differences in immune profiles, including reduced circulating memory and effector CD4 T cells (type 1 and type 2) and an increase in TNFα+ CD8 T cells. PVS participants also had lower anti-spike antibody titers, primarily due to fewer vaccine doses. Serological evidence of recent Epstein-Barr virus (EBV) reactivation was observed more frequently in PVS participants. Further, individuals with PVS exhibited elevated levels of circulating spike protein compared to healthy controls.

These findings reveal potential immune differences in individuals with PVS that merit further investigation to better understand this condition and inform future research into diagnostic and therapeutic approaches.

Link | PDF (MedRxiv preprint, February 2025, open access)
 
Anti-SARS-CoV-2 antibodies don't seem to be decreasing over time in the post-vaccination syndrome or control groups that had infections, but they do in the PVS group that was not infected.
The next step was to evaluate if the most recent exposure to SARS-CoV-2 or vaccination correlated with the observed differences in waning patterns. No significant changes in anti-S, anti-RBD and anti-N antibody levels were observed with an increase in the number of days from self-reported viral infection dates among the Control+I [I=infection] and PVS+I subgroups (Figure 3C).
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C. Correlation and linear regression comparisons of virus-specific ancestral anti-S, anti-RBD and Anti-N IgG levels by days post last exposure. Regression lines are shown colored by groups Control-I, Control+I, PVS-I, and PVS+I as indicated in the figure legend. Spearman’s ρ coefficients and linear regression significance are colored; accordingly, shading represents 95% confidence interval.
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Edit: I didn't see the very faint controls without infection also in figure 3C. Their antibodies also don't seem to be decreasing with time.
 
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Predictably, medicine's massive failure to take the many consequences of COVID seriously has become the biggest boost the conspiracy crowds have ever received. It should almost count as non-monetary donations. They will easily turn this into hundreds of millions.

Of course it does not bother them that LC was happening months before the vaccines, and this is something most of the general public would be able to argue and dismiss if they had been told what is what, but instead the need to cover up is leaving a massive void of credibility and it's being filled by money-grubbing trolls, with the general public having nothing to latch on to.

Alex Jones is one of the biggest conspiracy theorists out there. Huge audience.
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And "Died suddenly" is a propaganda film blaming most of the deaths from COVID on the vaccines. It also does not bother them that people were dying long before the vaccines happened. This is why experts need to always tell the truth. They only need to leave one void, make one blatant mistake, and it just gets amplified to all hell. But since most keep doubling down anyway, it's just endless gifts to the grifters.
They are finally admitting "Long COVID" is just vaccine injury
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https://twitter.com/user/status/1892382501261172922
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The following has been added to the Declaration of Interests section in a new version:
B.D. reports being a plaintiff in a lawsuit against AstraZeneca alleging breach of contract following her volunteer participation in 2020 in their COVID-19 vaccine clinical trial. She is also a co-chair of REACT19, a non-profit organization offering financial, physical, and emotional support for those suffering from long term COVID-19 vaccine adverse events. D.H serves on the Advisory Board of REACT19.
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'No, COVID-19 vaccines don’t suppress your immune system—here's the science'

'A recent preprint filled with fundamental scientific flaws is fueling anti-vaccine disinformation.'

The big takeaways:
  • The study did not accurately correct for past infection. The methods used to “exclude” past infection as a variable is not accurate–the data presented actually suggest everyone has a similar history of past infection, which means the PVS symptoms reported by participants cannot be automatically attributed to vaccination.
  • The study didn’t actually assess T cell exhaustion. In order to actually do that, they would have needed to show markers of T cell exhaustion (TIM-3, CTLA-4, PD-1, etc) combined with reduced function (lower cytokine levels, reduced proliferation), metabolic defect, and gene expression changes. They don’t do any of this. In fact, IFN-γ and TNF-α are comparable in “PVS” samples and controls.
  • They did not even use a method to assess EBV reactivation. They only look at antibody levels against EBV proteins–an indication of past exposure to EBV and memory immune response. They did not assess EBV replication, which is required to show reactivation.
  • CD4 T cell populations aren’t actually different between groups and all are within normal ranges for healthy individuals. Effector memory cells are within the “healthy” range in both groups. There were no meaningful differences between the groups, or a divergence from normal ranges.
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forestglip said:
'No, COVID-19 vaccines don’t suppress your immune system—here's the science'

'A recent preprint filled with fundamental scientific flaws is fueling anti-vaccine disinformation.'
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Just to highlight this article comes within a hair of calling long covid pseudoscience when it criticises Putrino.

Also, do we see any of these markers the article author names that would need to be present to actually show T Cell exhaustion in the recent Hansen paper? Or in the intramural study?
 
V.R.T. said:
Just to highlight this article comes within a hair of calling long covid pseudoscience when it criticises Putrino.
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I don't think she makes any claim about anyone's symptoms not being real. She's calling out any unevidenced mechanistic explanations.

David Putrino has made quite a name for himself by spreading disinformation about pseudoscience diagnoses like chronic Lyme. (see the American Lyme Disease Foundation for more).
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What she cites says that symptoms persisting after Lyme are real, but there's little evidence of persistent Lyme bacteria infection.
Sometimes, the phrase chronic Lyme disease is referring to Post-Treatment Lyme Disease Syndrome (PTLDS). [...] PTLDS is a medically accepted condition where patients continue to experience symptoms after the completion of standard antibiotic treatment for Lyme disease.
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More often, though, chronic Lyme disease is used as a diagnosis to refer to a chronic and persistent case of Lyme disease [...] this concept is not accepted by credible infectious disease experts and among the broader medical community because it lacks robust scientific evidence. Reputable medical authorities, including the CDC and IDSA (Infectious Diseases Society of America), do not recognize “chronic Lyme disease” in this context due to the lack of scientific proof of persistent infection.
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Perhaps I misread it. It was the juxtaposition of the psuedoscience comment and the tweet below.

V.R.T. said:
Also, do we see any of these markers the article author names that would need to be present to actually show T Cell exhaustion in the recent Hansen paper? Or in the intramural study?
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This is the more important question, I think. Would be interested if anyone knows the answer.
 
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