I've tried LDN 2 or 3 times in my lifetime.
The first consignment was titrated and encapsulated by a compounding pharmacy in the US, and shipped to me, here in the UK. It did nothing... Nothing at all. I can't really be sure what was in the capsules. I relegated LDN to the domain of failed treatments for the next 15 years (it sounded too good to be true anyway).
The second batch of LDN arrived courtesy of Breakspear Hospital, supplied by a Scottish pharmacy, but not Dickson Chemist, another one, whose name I can't recall right now. 3mg capsules. Hmm, it appeared to have some bioactivity... interesting! But I couldn't be sure, and had other treatments queued up. Another 2 years passed by.
Then I got word of Dickson Chemist and the set up there (availability of GP telephone consultation), and managed to get my head together and follow the process to obtain myself some of their finest LDN. It comes as a sort of cough medicine liquid that you can measure out with an oral syringe, to ramp up your dose. I can tell you that Dickson know what they're doing when it comes to LDN. This stuff had far more impact than my previous ventures into LDN. There may be various reasons for this, one of which is that it's important the naltrexone be rapidly absorped to convincingly yet temporarily block the opioid receptors.
What benefits did I get? Reduced inflammation, and what I felt could be reduced neuroinflammation (if that's a thing) - improved cognition and I felt more like my old self, from a long time ago, it was a weird sense of revisiting my old self. So; less body ache, brain working better, more energy, able to accomplish more with my time. Oh yes, I've just remembered, better gut function, it cleared up some mild IBS symptoms I'd had for several years.
All of this lasted about 6 weeks, then started tailing off and then I got a respiratory infection (upper respiratory tract infections are the bane of my life, so it was very unusual to go 6 weeks in November/ December without one, up to this point). I continued to take LDN for 3 to 6 months on and off, no longer sure if it was providing an overall benefit. The problem I had with it eventually, which is an issue with many meds/ supplements I try (following adverse effects of Ciprofloxacin, and Roaccutane), is that it caused drying out of mucous membranes, and this may have increased my susceptibility to/ diminished ability to recover from respiratory infections, in my case.
Otherwise, I didn't experience any significant side effects or problems with the LDN, only slightly disrupted sleep when becoming accustomed to the dosage and, maybe, more vivid dreams.
I would welcome a clinical trial into the use of LDN for ME/CFS.
