News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

"Hello everyone! I'm busy wrapping up a grant application and just wanted to give a quick update on my remote clinical trials. Next week I will be presenting a new treatment approach for chronic pain, headaches, and anxiety. - Jarred Younger"

https://www.youtube.com/watch?v=AwM1GW_R7Ew

 

"Daily green light treatment may reduce fibromyalgia pain by 50%. I'll cover that research and let you know what I think about the approach. The published report is at the link below. - Jarred Younger

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861466/ "

"Here is a Health Rising article by Cort Johnson if you want some more background info on green light phototherapy: https://www.healthrising.org/blog/2...herapy-fibromyalgia-chronic-fatigue-syndrome/ "

https://www.youtube.com/watch?v=h7drFS-3Grg

 

Ahem.

I'd place bets that people get better results from actually being in natural green environments rather than a green light (will make money for someone) therapy, but I may be prejudiced.

My medical reporter father hid in a garbage can in the 1950s at a chiropractic convention where red light was the promoted miracle cure.

 

This guy…..

 

"My clinical research shows that stinging nettle may reduce widespread musculoskeletal pain. I will cover in this talk whether it is worth trying. If you want to see the original study, click on one of the open-access links at the page below. - Jarred Younger

https://pubmed.ncbi.nlm.nih.gov/33915962/ "

https://www.youtube.com/watch?v=CgvxljIy_j0

 

Sorry @mango for taking your video posting job this week!

https://www.youtube.com/watch?v=vePEtCKjkfA

AI generated summary:

"The video discusses the lab's top 8 research priorities for the second half of 2024:

1. Botanical trial for Gulf War Illness:
- Remote trial looking at curcumin, stinging nettle, and R-lipoic acid
- Open to participants from anywhere in the US
- About halfway through the trial, laying groundwork for future remote trials

2. Zirconium-89 oxine PET study:
- Tracks leukocytes infiltrating the brain and causing inflammation
- Done in collaboration with Jonathan McConathy and Suzanne Lapi
- Healthy controls completed, starting to run ME/CFS patients

3. DPA-714 PET study:
- Shows when microglia in the brain are activated and inflamed
- Aims to determine if ME/CFS patients have inflamed brains
- ME/CFS patients completed, 4-5 healthy controls left
- Funded by NIH

4. Brain inflammation MRI study:
- Looks at brain temperature and lactate as signs of inflammation
- Almost done, trying to finish in second half of 2024
- Also NIH funded

5. Psilocybin for fibromyalgia pain clinical trial:
- Giving macro doses of psilocybin to fibromyalgia patients
- Investigating if it changes serotonergic systems to reduce pain
- Most will run in second half of 2024

6. Weather and pollutant effects on ME/CFS study:
- By graduate student Chloe Jones
- Correlates daily fatigue ratings with weather/pollutant data
- Preliminary results show some variables fluctuate with good/bad days

7. Developing dextro-naltrexone:
- Aim to create more powerful version of low-dose naltrexone
- Hoping to start the project this year
- Complicated as never used in humans before

8. Whole genome sequencing for ME/CFS:
- Run by Liz Worthey and Camille Birch, funded by Solve ME
- Identifies genetic variants likely driving a patient's primary symptoms
- First project finished, pending peer review, likely published by end of year
- Hope to eventually offer to anyone with mysterious pain/fatigue/cognitive issues"

 

All good! I'm a big fan of teamwork, thank you! (It's just one of those things that seems to randomly have turned into a kind of habit, unintentionally. No attachment whatsoever, though! )

 

"A new study identifies a key brain region for upregulating and downregulating inflammation. This site presents a new target for inflammatory and neuroinflammatory diseases. The paper is open-access and available here: https://www.nature.com/articles/s41586-024-07469-y

- Jarred Younger"

https://www.youtube.com/watch?v=71V4cbcUuok

 

Here is that brain stem again. I wonder how he is going to reconcile the brain stem with microglia. We don't need both to explain ME/CFS; we just need either hypersensitive brain stem or hypersensitive microglia. It's hard to imagine it is microglia in some cases (like infection) and brain stem in other cases (like CCI).

I'm still leaning towards microglia. If the "thermostat" is broken, the resulting (inflammation) temperature should deviate from the norm. But we don't see that in ME/CFS. We only see the afferent temperature signal knocking out the patient w/o the resulting temperature change.

 

"Here is some preliminary data from my lab on resveratrol for inflammatory pain and fatigue. It is still too early to recommend resveratrol for Gulf War Illness, fibromyalgia, or chronic fatigue syndrome. We are following up with a larger clinical trial right now. The paper is open access and can be reached here: https://pubmed.ncbi.nlm.nih.gov/33802381/ - Jarred Younger"

https://www.youtube.com/watch?v=e63h3eXJkWQ

 

Umm I’ll save you the time…..it doesn’t work.

 

"It is a little-known fact that chronic inflammation causes depressed mood. I want to show you where in the brain this occurs, and why it makes no sense to tell someone with FM, ME/CFS, GWI, MCAS, or other chronic conditions that they "are just depressed". - Jarred Younger"

https://www.youtube.com/watch?v=vsnTuOoOyRI