Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

Surely we've got enough models from the top of these stories for an ME Girls Calendar 2019 now? One symptom of ME which seems to have been overlooked so far is that it makes models collapse back into bed after their exhausting morning beauty routine, raising their hands to their fully made-up heads in despair. Just a selection from the latest round ...


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If we're not going to have a calendar, we really should at least have a christmas caption competition.
 

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NelliePledge said:
https://www.bbc.co.uk/programmes/p06mvpsw Possibly not accessible outside UK it was only shown here in November. It’s about a group of chimps in Senegal and there’s a power struggle
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I hadn't really understood why Edwards was referencing the Bilko episode where they're trying to beat records for inducting new recruits... but surely that's the only chimpanzee episode that really matters?:

 
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Sly Saint said:
It's going to get worse as there are 'branches' of the SMC in other countries and presumably they pass on their releases.

eta: I see the ME Association are also retweeting all the various articles (although have not spotted the ones with the Sun headline yet)



Michael Sharpe adding his words of wisdom:rolleyes:
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strategist said:
Have you seen the news about Karl Morten? He has found a lot of abnormalities and has just put in a £1.6 million bid to the MRC to expand that work.

He says the metabolic abnormalities in patients don't improve with GET.

What might be happening now is that the CBT/GET people are panicking and trying to preserve some space and funding for biopsychosocial approaches for vague fatiguing conditions. The Pariante paper is compatible with the CBT/GET model where the perpetuating factors are psychological.
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If Morton gets funding, can we get a preliminary statement into the media via the few journalists who think?
 
Trial By Error: The New Interferon “CFS” Study

I haven’t had time to cover the new and wildly over-hyped study about prolonged fatigue–and purportedly about “chronic fatigue syndrome”–that was published this week in the journal Psychoneuroendocrinology. Thanks no doubt to the involvement of the Science Media Centre, this mildly interesting piece of research has received widespread media attention.

Since the study team included confirmed members of the biopsychosocial ideological brigades, I remain wary of the motives of those involved. Even more so since this group of researchers apparently continues to define the illness using the discredited Oxford criteria, as they do in the Psychoneuroendocrinology study. This case definition requires only six months of unexplained fatigue and is known to generate heterogeneous populations of people suffering from a range of fatiguing disorders.
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http://www.virology.ws/2018/12/19/trial-by-error-the-new-interferon-cfs-study/
 
I've just read the interview with Nick Brown that was included in the article. It seems like "the data thugs" might be able to help us debunk some of the BPS work. Are they aware of the political reasons this piece of research is being hyped beyond all recognition? I am certainly interested in using the mathematical tools they developed to look for mistakes in papers. Particularly this one:

For those, Heathers came up with a somewhat more sophisticated test, which he and Brown call sample parameter reconstruction via iterative techniques, or SPRITE. In essence, SPRITE allows the researchers to do some reverse engineering: deriving statistically possible data sets from the means and standard deviations reported in a study.

James Heathers, Northeastern University
SPRITE has figured heavily in the pair’s analyses of papers by Cornell’s Wansink, who received extensive media coverage for his studies of nutrition and eating habits. The test showed that the data in at least one of his studies—a 2012 article in the journal Preventive Medicine looking at carrot consumption among school children—appeared iffy. How so? Running the published data through SPRITE showed that at least one child in the sample would have had to have eaten roughly 60 carrots in a single sitting. That amount, Heathers quips, is more appropriate for a cart horse than a child. (Wansink, who declined to be interviewed for this story, recently published a lengthy correction to the paper, stating it measured “matchstick carrots,” four of which are equivalent to one baby carrot.
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Edit: Because I pressed post accidentally before finishing writing!
 
Andy said:
http://www.virology.ws/2018/12/19/trial-by-error-the-new-interferon-cfs-study/
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That comment by EG makes little sense. She's an annoying distraction and is embarrassing herself.

Any way, I did leave my own comment...


The global media coverage of this research is not about the research.

It is about a group of people who have built their careers, reputations and bank accounts on their particular spin of the BPS model and their particular 'treatment', and are positioning themselves for further gains.

It is about orchestrating unfounded media coverage - again - to control the global ME narrative and to preserve their power in the light of overwhelming biological evidence - and at the expense of many millions of people living with ME world wide.

It is about the continued monetization of their egos - and of institutionalized medical harm.

 
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