Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome, 2018, Pariante et al

The Lever et al (1988) reference is this letter to The Lancet (if anyone has access).

The text in the book goes on to summarise this study account:

30 years have gone by, and we seem to be going backwards, not forwards. If researchers really were serious about catching this in the early stages, they should be actively looking for Coxackie B4 outbreaks. Where is Public Health in all this?

 

One thing I think is strange AFME haven’t covered this on Facebook, they usually publish media coverage for discussion. I looked on twitter and they started a thread there but hardly anyone replied. I’m not sure why They didn’t share this wider since the CMRC is there big thing.

 

Uh, oh! In my personal experience, men who refer to themselves as "alpha-males" seem more like beta-males to me. I don't personally know any actual apes.

 

I've just done a transcript (getting to be a habit this) of Pariantes interview on Radio 4; quite different from the one with @JohnTheJack .

 

That’s just inaccurate from the start because whilst not yet explained it’s not a mystery. Mystery in peoples minds equates to nothing known , nothing can be found, not serious like real disease, PS factors important

 

MH category and cLassification is there for a reason. Someone turns up in A & E, knowing they have serious mental health issues, or serious physical illness is useful to determining appropriate care. I am reluctant to go onto the Leeds inpatient service in a mental health ward because I’m aware of this difference and don’t feel confident the nurses will have appropriate understanding and approach to my illness, debilitation and physical sensitivities.

He says now we need to look at....
Basically he’s saying what we need to do is look at the physical changes that post infection are perpetuating the illness, well isn’t that what biomedical research advocates have said necessary for decades whilst his college put main emphasis on PS perpetuators. Did it Take this study to actually get to this level.

 

Thanks so much for that.

 

Their CEO is off, having surgery, so I suspect some of their other activities may be reduced for a while.
Hopefully they are concentrating on removing BPS info from their website.

 

So in the Radio 4 interview Pariante said:

And in the BBC Wales interview he claimed:

So he is actively promoting the confusion. I don't think this qualifies as a mistake. I think this demonstrates he is deliberately lying to gain personal benefit from it.

The fact that the paper only reported the measurements at 4 weeks and not at other timepoints also seems highly questionable.

Perhaps one of the ME organisations should write a critique of these questionable practices by the Pariante team?

 

Would that not be a breach of "big tent" rules.

 

Great find!

 

Is @Keithgeraghty on here?

Pariante made a statement in 2012 that ME was caused by excessive rest in predisposed individuals. I think I have seen this here ( not sure) and cannot find it, but Keith has I believe tweeted about it with full context. I don’t tweet so can’t investigate further.

I would like to hear Pariante questioned about whether this is still his belief, which I think is reasonable in the light of the huge publicity given to his small piece of research.

ETA:’ and cannot find it ‘ added in para 2

 

Not to mention contacting GPs who have done their CPD webinars and letting them know that the info is not pukka.

 

He wrote it in a review comment a while ago...

Here's Keith aluding to it here...
https://twitter.com/user/status/841214874436923392


[I'll edit this post when I find the relevant statement]

Got it!
https://twitter.com/user/status/838001798971523073

 

This must be reference to the paper referenced in this thread?

https://twitter.com/user/status/837720076774223873