The biology of coronavirus COVID-19 - including research and treatments

This paper doesn't seem very popular:

https://twitter.com/user/status/1254030253854543872

 

No, not a lot going for it .

 

Science Magazine: Pepcid for COVID-19?:

 

Guardian: More cases of rare syndrome in children reported globally (link)

 

Okay, now I understand why all the online stores were out of this drug! My husband is the one who takes it (he just takes whatever generic famotidine he can find).

Back in March we had no trouble getting some online but we tried to get a refill a day or two ago with no luck.

 

@Leila - and here in this thread @Michelle, as I just noticed again - posted that recently cases of the Kawaski Syndrom have slightly risen. I too saw it yesterday in TV. In England newborns displayed it. An association with corona comes to mind, but corona tests didn´t confirm it in that significance.

In case that it has to do with corona, directly or maybe indirectly, this article might especially be of importance:

Open Access Published: 10 November 2011
Association of Kawasaki disease with tropospheric wind patterns
Xavier Rodó et al, Scientific Reports volume 1, Article number: 152 (2011) Cite this articl


Abstract
The causal agent of Kawasaki disease (KD) remains unknown after more than 40 years of intensive research. The number of cases continues to rise in many parts of the world and KD is the most common cause of acquired heart disease in childhood in developed countries. Analyses of the three major KD epidemics in Japan, major non-epidemic interannual fluctuations of KD cases in Japan and San Diego and the seasonal variation of KD in Japan, Hawaii and San Diego, reveals a consistent pattern wherein KD cases are often linked to large-scale wind currents originating in central Asia and traversing the north Pacific. Results suggest that the environmental trigger for KD could be wind-borne. Efforts to isolate the causative agent of KD should focus on the microbiology of aerosols.

 

Thank you, very interesting.

(Interestingly in our disease there has also been made - twice I think - an association between mt genetics and symptoms - but not with prevalence or onset. There is no inherent mitochondria dysfunction, everything could be fine again in this respect.)

 

This is worth a look. It reports on a small number of children who have developed an inflammatory condition that in many cases seems to have been triggered by COVID19:

https://www.theguardian.com/society...n-children-reported-globally?CMP=share_btn_tw

There are some interesting parallels to ME.

 

Dr. Anthony Fauci was very excited yesterday regarding the antiviral drug Remdesivir 'blocking the virus'.
https://www.niaid.nih.gov/news-even...esivir-accelerates-recovery-advanced-covid-19

They may never be able to develop a vaccine, but drugs are looking promising to manage the illness.

 

New Scientist: What four coronaviruses from history can tell us about covid-19

The rest is behind a paywall...

 

https://books.google.de/books? "Diverging Paths of Developing in Central Asia." Edited by Özcan, 2017, page with Figure 7:

This might match up with NO2 -> lL-6 -> covid-19 in a complex manner.

 

Remdesivir is ineffective at reducing viral load (once already infected) or reducing mortality in COVID patients.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31022-9/fulltext

Do not believe the hype from the USA.

 

"The frequent use of corticosteroids in our patient group might have promoted viral replication, as observed in SARS and MERS, although these studies only reported prolongation of the detection of viral RNA, not infectious virus. Furthermore, we have no answer to whether longer treatment course and higher dose of remdesivir would be beneficial in patients with severe COVID-19".

Wouldn't this be an important factor as to why the studies differ?

 

There were no statistical differences in corticosteroid use between the patient and placebo groups (numerically, slightly higher in placebo group).

The US study may well have allowed patients to use corticosteroids too.
Note that the US study changed their primary outcome (from published protcol) to something far less stringent.

 

Interesting thread
https://twitter.com/user/status/1256242036015063042

 

From that thread

 

Interesting to know who have shares in Gilead and who will profit.

 

AIM ImmunoTech inks deal to research vaping device as a vehicle for Ampligen to treat coronavirus

https://www.proactiveinvestors.com/...for-ampligen-to-treat-coronavirus-916966.html