The biology of coronavirus COVID-19 - including research and treatments

Pulling a PACE, uh?

 

"AbCellera and Lilly to Co-develop Antibody Therapies for the Treatment of COVID-19":

https://www.abcellera.com/news/2020-03-abcellera-and-lilly-codevelopment

ETA: a search for "AbCellera" on this website didn't show anything; apologies if this has already been posted.

 

The hype seems to be spreading..

Lovande resultat för coronamedicin i stor studie

https://www.svt.se/nyheter/vetenskap/lovande-resultat-for-coronamedicin

 

'Happy hypoxia': unusual coronavirus effect baffles doctors
Some patients who appear not in distress are found to have dangerously low oxygen levels

 

Dagens Nyheter:Rehabiliteringen av covid 19-patienter stor utmaning för vården
https://www.dn.se/nyheter/sverige/r...C_J6mYbFLWC-vCCFWYkyRXVentR13OoqcCEuW_1Kdozvo

"Rehabilitation of covid 19 patients is a major challenge for healthcare
Healthcare is mobilized to help patients struggling for life in the acute stage of covid 19.

"But even now we must also take care of those who have been discharged and have received extensive damage from the infection," says Kristian Borg, a professor of rehabilitation."

English Google translation :
https://translate.googleusercontent...arden/&usg=ALkJrhjlJ3eqFLIpDI5M5SaUR0rza75cVg

 

Preprint
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

https://www.nature.com/articles/s41586-020-2286-9

 

was just thinking that if CRP testing in GPs had become standard practice (eg http://www.pulsetoday.co.uk/clinica...-to-help-cut-antibiotics-use/20037084.article) it might have helped to identify a lot of people with SARS-Cov2 earlier.........

(On tv last night there was someone who had CV and was being discharged from hospital, who said her GP prescribed antibiotics and corticosteroids when she first became symptomatic a month or so ago).

 

I couldn't agree more.

Opinion piece in Dagens Nyheter:
https://www.dn.se/ledare/erik-helmerson-notan-for-rehab-blir-dyr-i-bade-pengar-och-lidande/

https://translate.googleusercontent...dande/&usg=ALkJrhhLT3MDmAMRArcn3u-Ig63-JaTPDQ

 

A human monoclonal antibody blocking SARS-CoV-2 infection

Abstract
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19."

https://www.nature.com/articles/s41467-020-16256-y

 

If only that were true. It really should. The reality instead is mostly "out of sight, out of mind (and nevermind the complaints)".

 

Yes, the reality is very saddening and short-sighted.
There doesn't seem to have been any long term analysis made before implementing this strategy except for the effects a lockdown would have on the economic system (but is there ever in politics?)

To be fair there wasn't much knowledge about the dramatic consequences for many of the survivors at the beginning of the pandemic, but now that we know better, shouldn't we do better?

 

Evidence that SARS-CoV-2 has been around longer than assumed.

https://www.france24.com/en/20200505-france-s-first-known-covid-19-case-was-in-december

Personally I am wondering if a nasty cold I had at the beginning of December, which had all the same symptoms, including dry cough and losing taste and smell which I actually wrote in my diary, was in fact Covid 19. I will try to get a post infection test when it becomes available.

 

https://twitter.com/user/status/1257828922638700546

 

Notably the study revealed that 99% of patients seroconverted, a number of people are being falsely diagnosed with COVID19 (they probably have other viral infections), and the usual accuracy limitations of the tests.

The fact that viral fragments continue to be detected is not atypical of viruses and suggests prolonged low level infection for some time. (note that the authors don't suggest that individuals are infectious after the patients feel like they have recovered)

The last few nasty viruses I had, hit me for several waves over a period of 6 weeks so it doesn't surprise me personally (never felt completely well).

 

Scientists say a now-dominant strain of the coronavirus appears to be more contagious than original

Particularly interesting given earlier discussions on this thread and others about the virus mutating. Scary.

 

Pre-print, but interesting.

https://osf.io/usztn/

 

https://twitter.com/user/status/1258060081884794886