Review The expanding potential of low-dose naltrexone in clinical practice with a focus on long COVID, 2026, Pucci et al

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The expanding potential of low-dose naltrexone in clinical practice with a focus on long COVID

Pucci, Sara L.; Veide, Allison; Pierce, Haley; Kaminski, Dana

Practice Points
1. Use of low-dose naltrexone, typically dosed between 3 and 5 mg, is increasing in clinical practice for indications such as fibromyalgia, chronic pain syndrome, and post-COVID chronic fatigue syndrome.

2.Evidence for the use of LDN in chronic pain syndrome, fibromyalgia, and post-COVID chronic fatigue syndrome is limited to small studies; however, the promising results of pain and other symptom reduction warrant additional research.

3. LDN is generally well-tolerated and is a potentially safe option for patients.

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