Highlighted links from the May 2026 report (from a recent email update)

- RECOVER builds on existing knowledge about how Long COVID can affect the lungs and heart.
RECOVER researchers continue to study how SARS-CoV-2, the virus that causes COVID-19, spreads through the lungs and eventually impacts other body systems, such as the heart and nervous system.
Difficulty breathing is one of the most common symptoms of Long COVID. However, researchers can’t assume that all patients who have difficulty breathing have problems with only their lungs. “People can have shortness of breath for multiple reasons, including problems with the lungs, heart, bone marrow, and the brain,” said Dr. Krishnan, who is the lead principal investigator for ILLInet, the RECOVER study hub at the University of Illinois Chicago.

- RECOVER continues to accept research proposals for ancillary studies that use data and biosamples collected during RECOVER studies.
RECOVER ancillary studies allow researchers inside and outside of the RECOVER Consortium to answer important questions about Long COVID. These studies may use RECOVER biospecimens (such as blood, saliva, and urine) or combinations of biospecimens and data to answer research questions beyond the main RECOVER study objectives (protocols).

- Participant advisory group at RECOVER hub raises awareness about Long COVID
For the members of the ILLInet PARATROOPers—a participant advisory group at a RECOVER study hub—taking part in the group provides both the opportunity to be heard and the chance to connect with people locally who are living with Long COVID.

The PARATROOPers (which named themselves after letters included in “Participant Research Work Group”) include people living with Long COVID and participating in RECOVER’s adult observational study at ILLInet, RECOVER’s hub at the University of Illinois Chicago. The group formed shortly after Amy Pope, one of the group’s first co-chairs, was considering withdrawing from the study. Her ride to a required in-person study visit fell through, and she felt the study as a whole could be more authentic and valuable to people living with Long COVID.
 
"RECOVER Research Update: June 2026"
Since March 2026, RECOVER researchers have published 9 papers in scientific journals. These papers cover a range of topics, including:
  • The impact of vaccination on Long COVID in children.
  • How Long COVID can make it harder for children to perform well in school.
  • Pre-existing sleep problems as a risk factor for Long COVID in adults.
  • How people from all backgrounds and walks of life can help inform Long COVID research.
Keep reading to stay up to date on the progress being made by RECOVER’s clinical trials, pathobiology studies, observational cohort studies, and electronic health record (EHR) studies.
 
RECOVER Research Update: June 2026

Recent publications from RECOVER describe the unique effects Long COVID can have on children, identify changes in the body that may contribute to Long COVID symptoms, and explain how RECOVER has tested possible treatments for different symptoms of Long COVID.

 
"RECOVER launches second phase of adult observational study"

Fewer in-person study visits and improvements to symptom surveys will help reduce burden for study participants.

In May, RECOVER officially launched the second phase of the adult observational study. This next phase will continue to follow about 5,000 adult participants from the almost 15,000 people who took part in the first phase.

“The next phase of the observational study is primarily about extending what we have been doing in the first phase, with some refinement,” said James Chan, MA, MEd, a senior biostatistician who works with RECOVER’s Data Resource Core. “Surveys should look very familiar to participants with some adjustments to reduce participant burden. We have also rebuilt our data capture system to greatly reduce load times.”
 
"Immune system may attack nervous system in some Long COVID patients"


At a Glance
  • Researchers linked antibodies that attack the body’s nervous system to some neurological symptoms of Long COVID.
  • The results may point to possible treatments for some people with Long COVID.
A team of NIH-funded scientists, led by Drs. Akiko Iwasaki and Tamas L. Horvath of the Yale University School of Medicine and Dr. David Putrino of the Icahn School of Medicine at Mount Sinai, recently investigated the role of autoantibodies in neurological manifestations of Long COVID. The results of their research were published in Cell on May 28, 2026.

The scientists first studied antibodies from the blood of 147 people. Antibodies from patients with Long COVID and people who recovered from COVID reacted more often to human nervous system tissue than those of healthy people.

Long COVID patients whose autoantibodies targeted specific proteins or parts of the brain were more likely to have a set of similar symptoms. For example, people with autoantibodies targeting a brain area called the locus coeruleus were more likely to have lost their senses of taste and smell. They were also more likely to experience nausea and joint pain.

The team injected antibodies from the Long COVID patients into mice to see if the antibodies could cause Long COVID symptoms. They found that the test mice were more sensitive to pain if they received antibodies from Long COVID patients with chronic pain. Those mice also showed signs of nerve damage linked to chronic pain. Most of the mice that developed balance instability had received antibodies from patients with dizziness. The test mice also tired more quickly when placed on a moving treadmill.

“It is remarkable that mouse behavior mirrored some of the patients’ symptoms after their antibodies were transferred,” Iwasaki says.
This NIH article is about the study in this thread:

"A causal link between autoantibodies and neurological symptoms in long COVID"

 
"RECOVER-TLC to host next webinar July 16, 2026"


The National Institute of Allergy and Infectious Diseases (NIAID) and the Foundation for the National Institutes of Health (FNIH) will host the next RECOVER-Treating Long COVID (RECOVER-TLC) webinar on Thursday, July 16, 2026, from 1:00-2:00 pm ET.

Topics to be covered during this online event include:
  • What happens during a clinical trial.
  • What people interested in taking part in clinical trials need to know about participant safety, the enrollment process, and more.
  • How clinical trial findings can guide improvements in patient care.
  • The current status of the RECOVER-TLC clinical trials. These trials will test 4 possible treatments for a range of Long COVID symptoms affecting both children and adults.
The webinar will also include a question-and-answer session. Anyone is welcome to submit comments and questions in advance.

Registration link
 
I've found this whole RECOVER thing hard to get my head around, so I've tried to make list.


RECOVER-TLC
  • Baricitinib - enrolling
  • GLP-1 receptor agonist - planning stage
  • Low dose naltrexone - planning stage
  • Stellate ganglion nerve block - planning stage

RECOVER-CT
  • RECOVER- VITAL: Paxlovid as a treatment - DIDN'T WORK

  • RECOVER-NEURO: Brain HQ - online cognitive training DIDN'T WORK
  • RECOVER-NEURO: PASC CoRE - online goal training DIDN'T WORK
  • RECOVER-NEURO: Transcranial Direct Current Stimulation DIDN'T WORK

  • RECOVER-AUTONOMIC: IVIG for severe POTS
  • RECOVER-AUTONOMIC: Ivabradine for moderate POTS

  • RECOVER-SLEEP: Modafinal and solriamfetol for insomnia
  • RECOVER-SLEEP: Melatonin and light therapy for complex sleep disturbances

  • RECOVER-ENERGISE: Exercise for exercise intolerance
  • RECOVER0-ENERGISE: 'Structured Pacing' for post-exertional malaise

Feel free to copy the list and make it correct or up to date, add links
Not holding my breath in anticipation for much from those studies.
 
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From RECOVER email:

Upcoming R3 Seminar: RECOVER clinical trial results and the pursuit of Long COVID treatments

Tuesday, July 14, 2026, 12:00–1:30 pm ET


This R3 Seminar will highlight findings from the RECOVER-NEURO and RECOVER-AUTONOMIC (Ivabradine) clinical trials, which focus on symptoms related to thinking, memory, and the autonomic nervous system—the system that controls body functions like heart rate and blood pressure. Results from these trials are helping researchers better understand which treatments may be effective for Long COVID and can guide next steps in clinical research.

Panelists will share how RECOVER designed these clinical trials, including how potential interventions are selected and how input from Patient, Caregiver, and Community Representatives helped inform each step of the process.

The seminar will also cover findings from a survey that included RECOVER Representatives who helped design these trials through Protocol Working Groups. Ongoing efforts like this to learn from Representative feedback and strengthen engagement are helping RECOVER and the broader research community build more inclusive and effective clinical trial networks.

Panelists include:
  • Marta Cerda, JD, RECOVER Representative
  • David Knopman, MD, Mayo Clinic
  • Renee Leverty, MA, BSN, Duke Clinical Research Institute
  • Pam R. Taub, MD, University of California, San Diego

Registration link
 
Key bits

RECOVER also launched the next phase of its adult observational study, which will enable an additional 2 years of study participation, data collection, and discovery. Similarly, the National Institutes of Health (NIH) decided to continue the RECOVER pediatric observational study for 2 more years. This may help researchers understand how children’s health changes over time and whether symptoms get better, stay the same, or get worse. In addition, researchers working on pathobiology and tissue pathology (autopsy) studies continue to make strides in understanding what happens inside the body when people are living with Long COVID.

RECOVER-CT continues to share findings from its 8 clinical trials, which have tested 13 possible treatments for Long COVID symptoms. In March, researchers shared initial results from the RECOVER-AUTONOMIC (Ivabradine) trial at the American College of Cardiology Annual Conference. A paper describing the full findings and analysis is expected to be published in the coming months.

Results from the RECOVER-VITAL clinical trial are also available on ClinicalTrials.gov. Researchers expect to publish a paper describing the full findings soon.

Following the links, here's what has been said about the Ivabradine trial - a null result
Participant surveys showed that treatment with ivabradine did not significantly improve POTS symptoms in adults with Long COVID POTS. Ivabradine did produce a significant reduction in heart rate compared to placebo, but the lower heart rate did not improve POTS symptoms. Participants who received coordinated care in addition to ivabradine did report an improvement in their symptoms compared to those who received ivabradine and usual care.


RECOVER-CT expects to share additional results later this year. Members of the team will provide an update on clinical trials at a RECOVER Research Review (R3) Seminar on July 14. Learn more about the upcoming R3 Seminar.
RECOVER-TLC will also hold its yearly workshop on Wednesday, November 4, and Thursday, November 5, in Bethesda, Maryland. Registration for the event will open in late September with options to attend online or in person.
Study plans for the GLP-1 RA trial (Tame-LC) and the SGB trial (Block-LC) have also been posted for public comment. Each trial’s Protocol Working Group is currently reviewing comments and making updates to the full study plans (protocols). Summaries of the comments and the resulting changes to the study plans will be posted to the RECOVER-TLC Collaborator Portal in the upcoming months.

In addition to receiving feedback through public comments and from community representatives participating in Protocol Working Groups, RECOVER-TLC has formed a Community Advisory Board, which includes 12 Patient, Caregiver, and Community Representatives. The Board meets each month to review and provide feedback on study plans, information, and recruitment materials for planned clinical trials; discuss best practices to reach communities impacted by Long COVID; and develop accessible, easy-to-understand resources for participants.

RECOVER-TLC continues to accept treatment ideas through its submission portal. Anyone can submit information about a drug, medical device, or other possible treatment that could help people suffering from symptoms of Long COVID.

A new research opportunity to expand pathobiology studies will open this summer. This opportunity will invite proposals that address critical gaps in our understanding, diagnosis, prevention, and treatment of Long COVID, including identifying biomarkers and mechanistic pathways for treatments. To learn more about RECOVER’s pathobiology research, explore the full list of studies and findings shared by researchers.
 
Some more from the report - about autopsy studies. That's something to watch.

Findings from the autopsy study have been made possible by the 304 people enrolled—with permission of their family or caregiver—in the autopsy study. The study enrolled its final participant on January 31, 2026. According to James Stone, MD, PhD, chair of the RECOVER Autopsy Cohort Coordinating Committee, the study also exceeded its enrollment goal for people with Long COVID. Enrolling more people with Long COVID in the study gives researchers greater opportunities to pinpoint changes in the body that lead to Long COVID—and eventually design treatments to stop or reverse those changes.

One key to achieving the study’s broader goals is sharing access to the biosamples collected through the autopsy study. Authorized researchers can access the biosamples and, in some cases, images of biosamples through the study’s Digital Slide Archive.

Before adding images to the archive, researchers may treat the biosamples, which are preserved on microscope slides, with chemicals called stains to reveal details in the tissues that would not otherwise be visible. Staining allows researchers to look closely at the tissues on the slides for specific COVID-related changes, like scarring, tiny blood clots, and cell damage, in different tissues and organs. The slides allow researchers to examine samples from more than 50 locations in the body, including the brain, heart, lungs, and gut. The study team anticipates that analyses of stained slides will be completed by the end of March 2027.

Dr. Stone also shared that researchers are preparing 2 additional sets of study findings for publication later this year. The first publication will discuss a study comparing causes of death in people with and without Long COVID. The second publication will discuss a study examining samples taken from the back of the throat and behind the nose (nasopharyngeal swabs) for evidence of viral persistence.
 
So, updating the list of RECOVER trials:
RECOVER-TLC
  • Baricitinib - enrolling
  • GLP-1 receptor agonist - planning stage
  • Low dose naltrexone - planning stage
  • Stellate ganglion nerve block - planning stage

RECOVER-CT
  • RECOVER- VITAL: Paxlovid as a treatment - DIDN'T WORK

  • RECOVER-NEURO: Brain HQ - online cognitive training -DIDN'T WORK
  • RECOVER-NEURO: PASC CoRE - online goal training -DIDN'T WORK
  • RECOVER-NEURO: Transcranial Direct Current Stimulation - DIDN'T WORK

  • RECOVER-AUTONOMIC: IVIG for severe POTS
  • RECOVER-AUTONOMIC: Ivabradine for moderate POTS - DIDN'T WORK

  • RECOVER-SLEEP: Modafinal and solriamfetol for insomnia
  • RECOVER-SLEEP: Melatonin and light therapy for complex sleep disturbances

  • RECOVER-ENERGISE: Exercise for exercise intolerance
  • RECOVER0-ENERGISE: 'Structured Pacing' for post-exertional malaise
 
Following the links, here's what has been said about the Ivabradine trial - a null result
That's interesting, because the people at my clinic say that ivabradine is best for treating Long Covid POTS. But it only reduces heart rate, not symptoms, so it's weird they're saying it can be used to treat it. I guess it makes me happier with my decision to stop trialling medications until something has better evidence and is actually approved.
 
Thanks for posting key points from the article, @Hutan !

I also thought this was interesting - adding plans to compare how the drug affects "participants who also have related health conditions."
(does this mean additional "arms" added to a study?)
In response to comments, the Protocol Working Group has added plans to examine how the drug affects participants who also have related health conditions, including dysautonomia, postural orthostatic tachycardia syndrome (POTS), post-exertional malaise (PEM), and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).
I think this is just for the LDN study but I'm having trouble reading/understanding the details.

I'm not sure why they listed PEM as a separate related health condition rather than a key part of ME/CFS (also part of some Long Covid cases).

So I'm glad for the mention of ME/CFS but I don't really understand what they are trying to do.
 
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