What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, CFS [...] ? (2019) Ryabkova et al.

[Sly Saint]

Review
Neuroimmunology: What Role for Autoimmunity, Neuroinflammation, and Small Fiber Neuropathy in Fibromyalgia, Chronic Fatigue Syndrome, and Adverse Events after Human Papillomavirus Vaccination?

Abstract
:
Fibromyalgia is a disorder characterized by chronic widespread pain and non-pain symptoms, such as fatigue, dysautonomia, and cognitive and sleep disturbances. Its pathogenesis and treatment continue to be the subject of debate. We highlight the role of three mechanisms—autoimmunity, neuroinflammation, and small fiber neuropathy—in the pathogenesis of the disease. These mechanisms are shown to be closely interlinked (also on a molecular level), and the review considers the implementation of this relationship in the search for therapeutic options. We also pay attention to chronic fatigue syndrome, which overlaps with fibromyalgia, and propose a concept of “autoimmune hypothalamopathy” for its pathogenesis. Finally, we analyze the molecular mechanisms underlying the neuroinflammatory background in the development of adverse events following HPV vaccination and suggesting neuroinflammation, which could exacerbate the development of symptoms following HPV vaccination (though this is hotly debated), as a model for fibromyalgia pathogenesis.

https://www.mdpi.com/1422-0067/20/20/5164/htm

 

[daftasabrush]

I just came across this today. What's your view?

I think OMF was looking into an autoimmune response causing / worsening ME, but only for a subset of patients.

Some of their early statements have very limited single success eg evidence of neuroinflammation in fibromyalgia - citing a single small only

The central sensitization hypothesis is based on very flimpsy evidence. The more I look into it the less there is.

I always find it a bit dubious to hear of overlapping symptoms between FM and CFS - just because many people have both doesn't make the a common origin involved - loads of illnesses have fatigue, brain fog, pain and insomnia. I notice that are using the newer FM criteria without the tender points so they will be finding a much larger group have CFS.