brain

Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) patients suffer from neurocognitive impairment. In this study, we investigated cortical volumetric and thickness changes in ME/CFS patients and healthy controls (HC). We estimated mean surface-based cortical volume and thickness from...

Sugar for the brain: the role of glucose in physiological and pathological brain function Philipp Mergenthaler, Ute Lindauer, Gerald A. Dienel, and Andreas Meisel Abstract The mammalian brain depends upon glucose as its main source of energy, and tight regulation of glucose metabolism is...

Abstract Background This multicentre study aimed to provide a qualitative and consensual description of brain hypometabolism observed through the visual analysis of 18F-FDG PET images of patients with suspected neurological long COVID, regarding the previously reported long-COVID hypometabolic...

Full title: Chronic cerebral aspects of long COVID, post-stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic Abstract The chronic neurological aspects of traumatic brain injury, post-stroke syndromes, long COVID-19, persistent Lyme disease, and...

Many infectious agents are capable of disrupting the normal functioning of the central nervous system (CNS) by invading the brain parenchyma. Some of these pathogens, for example encephalitic viruses and meningitis bacteria, cause acute perturbations, whilst the effects of others, such as prions...

https://osf.io/ef3n4/ The newsbrief posting reminded me that this paper wasn't mentioned. I think it may be a pretty important hypothesis for ME's root cause. It fits what I believe is the root cause of ME: that neuroglia are involved. I'm not sure whether there are any ME symptoms that...

Review of the Midbrain Ascending Arousal Network Nuclei and Implications for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Gulf War Illness (GWI) and Postexertional Malaise (PEM) Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS and Gulf War Illness (GWI) share...

Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain Preprint Abstract Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection frequently experience lingering neurological symptoms, including impairment in...

In mice. Highlights Altered metabolic features of microglia in the absence of host microbiota Bacteria-derived acetate modulates metabolic features of microglia during steady state Acetate regulates microglial functions during neurodegeneration Summary As tissue macrophages of the central...

Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM) preprint Abstract Background: Myalgic Encephalomyelitis / Chronic...

Abstract The Boston University-based Gulf War Illness Consortium (GWIC) is a multidisciplinary initiative developed to provide detailed understanding of brain and immune alterations that underlie Gulf War illness (GWI), the persistent multisymptom disorder associated with military service in...

Monitoring of cerebral oximetry in patients with postural orthostatic tachycardia syndrome Isabella Kharraziha, Hannes Holm, Erasmus Bachus, Olle Melander, Richard Sutton, Artur Fedorowski, and Viktor Hamrefors Link Abstract Postural orthostatic tachycardia syndrome (POTS) is a disorder of...

https://www.cell.com/cell/pdf/S0092-8674(21)01223-X.pdf Research done in mice. Highlights Neuronal ensembles in the InsCtx are activated during peripheral inflammation Reactivation of these neurons is sufficient to retrieve peripheral inflammation These InsCtx neurons project to autonomic...

https://www.bbc.co.uk/news/health-59140359

Abstract Rationale Chronic fatigue syndrome (CFS) is a common and burdensome illness with a poorly understood pathophysiology, though many of the characteristic symptoms are likely to be of brain origin. The use of high-field proton magnetic resonance spectroscopy (MRS) enables the detection of...

A significant proportion of COVID-19 patients are suffering from prolonged Post-COVID-19 Fatigue Syndrome, with characteristics typically found in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). However, no clear pathophysiological explanation, as yet, has been provided. A novel...

An article from neuroscience news . Interesting in the metabolism link , given we know of issues with glucose in ME. https://neurosciencenews.com/hippocampal-memory-blood-sugar-19108/amp/

In mice. https://www.biorxiv.org/content/10.1101/2021.08.02.454769v1 TL;DR: microglia can influence cerebral vasculature. (Paragraphs mine for legibility) Microglia are brain-resident immune cells with a repertoire of functions in the developing, mature and pathological brain. Their...

Full title: A paradigm for chronic fatigue syndrome: caught between idiopathic intracranial hypertension and spontaneous intracranial hypotension; caused by cranial venous outflow obstruction ABSTRACT Background Clinical similarities between chronic fatigue syndrome and idiopathic intracranial...

Abstract Aims There is controversy about brain volumes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (CFS) and Gulf War Illness (GWI). Subcortical regions were assessed because of significant differences in blood oxygenation level dependent signals in the midbrain between these...