genetics

I'm looking for evidence for a genetic component in ME/CFS and a discussion of the quality of evidence for each the studies. Here are some I found after a quick search (haven't read them all), are there important ones missing? Hickie et al. 2001. A Twin Study of the Etiology of Prolonged...

Open access, https://www.tandfonline.com/doi/full/10.1080/24740527.2020.1712652

https://pubmed.ncbi.nlm.nih.gov/32658146/ No idea if this is a promising lead or not, but here is a thread of one of the PIs explaining what they found

Moderator note: Please note: at this point only people from the UK will be eligible to participate in the study. However people from anywhere, with or without ME/CFS, can register their interest in receiving updates about the study. People who register will receive information about...

Provisionally accepted opinion article in frontiers in Pediatrics - Paediatric Neurology Review of the Quality Control Checks Performed by Current Genome-Wide and Targeted-Genome Association Studies on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome by Nuno Sepulveda, Anna D. Grabowski...

https://www.frontiersin.org/articles/10.3389/fimmu.2020.00578/full Excerpt: In conclusion, our study shows that the PTPN22 rs2476601 and CTLA4 rs3087243 autoimmunity risk variants are more frequent in patients with ITO ME/CFS. This finding provides further evidence that there is a genetic...

From Article: How sick will the coronavirus make you? The answer may be in your genes By Jocelyn KaiserMar. 27, 2020 , 3:25 PM https://www.sciencemag.org/news/2020/03/how-sick-will-coronavirus-make-you-answer-may-be-your-genes# the projects website: https://www.covid19hg.com/ @Chris Ponting

I searched but couldn't find this here, which is surprising. I've also Googled and can't find details of this elsewhere...

" Women's Health Clinical Trials We are currently recruiting women and men for all of the following studies in the Greater Cincinnati (Ohio) area: Fibromyalgia Studies In these studies, we are testing new medications for the treatment of fibromyalgia symptoms in adolescents and adults...

Pilot assessment of low NK cell-mediated ADCC and FCGR3A genetics in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Based on inclusion of family members without ME/CFS as controls, low ADCC is unsuitable as a diagnostic biomarker Alexander P. Sung, Jennifer J-J Tang, Michael J...

Background The metabolic trap hypothesis being investigated by the OMF is currently investigating IDO2, with the Severely Ill Big Data Project finding IDO2 mutations in the 20 patients ill with M.E. This question is about how someone can check if they have the mutations found based on genetic...

Paywall, https://academic.oup.com/bioinformatics/advance-article-abstract/doi/10.1093/bioinformatics/btz686/5559486 Sci hub, https://sci-hub.se/10.1093/bioinformatics/btz686

Researchers propose deep trawl of DNA to help uncover the causes of ME/CFS Analysing the DNA of thousands of patients can help to uncover the genetic roots of diseases and shed light on the underlying biological mechanisms. This can reveal targets for drug development. A new and very different...

https://www.theatlantic.com/science/archive/2019/05/waste-1000-studies/589684/

Genetic Predisposition for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study Melanie Perez1, 2, Rajeev Jaundoo1, Kelly Hilton1, 2, Ana Del Alamo1, 2, Kristina Gemayel1, Nancy G. Klimas1, 2, Travis J. Craddock1, 3* and Lubov Nathanson1, 2* Provisionally accepted; full text...

Access via Twitter. Very interesting research re genetic memory and re- engagement of fetal development genes. Of specific interest for cancer and aging, but by pressing methylation on / off switches , perhaps has relevance for ME too...

Struggling at the moment to find more details about this, if/when I do I'll edit them in here. From https://cureme.lshtm.ac.uk/researchers/our-collaborative-researchers/ ETA: Added detail from the CureME collaborators page.

Source: Clinical Therapeutics Preprint Date: March 6, 2019 URL: https://www.sciencedirect.com/science/article/abs/pii/S0149291819300475 Treatment avenues in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A split-gender pharmacogenomic study of gene-expression modules...

Provisionally accepted https://www.frontiersin.org/articles/10.3389/fped.2019.00059/full full paper here: http://sci-hub.tw/https://www.frontiersin.org/articles/10.3389/fped.2019.00059/full I haven't read it all but not sure if I've posted it in the correct forum?: "EBV reactivation is a...

https://www.mirror.co.uk/news/uk-news/veterans-debilitating-gulf-war-syndrome-13911872