long covid

https://clinicaltrials.gov/study/NCT05798221?id=NCT05798221&viewType=Card&rank=1&tab=study Complementary Self-help Strategies for Patients With Post-COVID-19 Syndrome (NASH-POCO) ClinicalTrials.gov ID: NCT05798221 Brief Summary Individuals affected by SARS-CoV-2 infection may subsequently be...

Background: Prior to the COVID-19 pandemic, the etiology of postural orthostatic tachycardia syndrome (POTS) remained elusive. Since the pandemic, a newly recognized disorder, termed Long COVID, has emerged with a significant subset of patients developing dysautonomia and a multitude of...

Evaluation of neuronal and immunological biomarkers in post-COVID-19 condition Highlights Plasma biomarkers reveal persistent inflammation in post-COVID condition (PCC) volunteers. Volunteers with neurological symptoms PCC-NS showed high IgA levels. PCC-NS volunteers presented elevated...

Systematic review of randomized clinical trials for the treatment of long COVID syndrome Background There is a critical need for interventions for long COVID. Our aim was to conduct a systematic review on the efficacy and safety of different interventions in patients with long COVID...

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS-CoV-2 infection (Neuro-PASC) between females and males. Methods Cross-sectional study of the first...

Post-Acute Sequelae of COVID-19 Across 15 Major Health Domains and 67 Diseases in Individuals With Depressive Disorder: A Korean Nationwide Cohort Study Abstract Background Individuals with depressive disorder often face barriers in accessing healthcare; however, research on the acute and...

Ozone therapy by rectal insufflation in long COVID syndrome: a preliminary study with thermographic evaluation and quality of life measurement Abstract Introduction Post-acute coronavirus disease 2019 syndrome (PACS) is a multisystemic clinical condition that clinically starting weeks or...

At the Icahn School of Medicine at Mount Sinai, the neuroscientist and long COVID expert David Putrino is collecting blood samples from some of the patients who responded well to Vyvgart. He hopes the samples could enable better immune phenotyping so clinicians can predict whether a person with...

https://cen.acs.org/pharmaceuticals/drug-development/long-covid-pots-mecfs-drug-trials-ethics/104/web/2026/07 4000-word article. Access to potential long COVID drugs dwindles as trials falter Two sets of studies for COVID-driven conditions show the struggles of drug development by Rowan Walrath...

Small extracellular vesicles proteome reveals persistent inflammatory and coagulopathic dysregulation in long-COVID Background Post-acute sequelae of SARS-CoV-2 (PASC) or Long-COVID affects millions and remains mechanistically undefined due to its heterogeneous clinical presentation...

Utilizing Wearable Technology to Characterize and Predict Post-Exertional Malaise Crashes across Post-COVID Syndrome and Chronic Inflammatory Conditions: Study Protocol of the prospective observational study ‘U-WaTCH’ Abstract Background: Fatigue and post-exertional malaise (PEM) are...

Time to Recovery from Long COVID: A Longitudinal Analysis of Symptom Duration and Risk Factors Using Accelerated Failure Time Models Highlights Long COVID symptom duration quantified using Accelerated Failure Time models over 22 months among 757 infected participants and 558 controls in...

Unpacking The Neurobiologic Origin Of Psychiatric Symptoms In Long Covid Claire Megan Perry Background Neuropsychiatric Long COVID (LC) is a heterogeneous and debilitating disease spanning multiple mental health symptom domains including depression, anxiety, cognitive dysfunction, fatigue, and...

Association between dietary inflammatory index, empirical dietary inflammatory patterns and the risk of Long COVID: a prospective cohort study Background Inflammatory responses and immune dysregulation are considered core mechanisms of Long COVID. Given that diet can modulate systemic...

Microstructural alterations in brain tissue of ME/CFS and long COVID using diffusion tensor imaging and diffusion kurtosis imaging Singh, Tanoj Bahadur; Marshall-Gradisnik, Sonya; Barnden, Leighton; Eaton-Fitch, Natalie; Huynh, Tuong Hieu; Inderyas, Maira; Thapaliya, Kiran Introduction...

Fatigue in Long COVID (FALCON) Study registration: https://clinicaltrials.gov/study/NCT07697261 Lead researcher: Jason Busse Long COVID affects about 6 in 100 people after a COVID-19 infection. It can cause ongoing problems like ongoing tiredness, muscle pain, and "brain fog." We know very...

Fatigue after COVID-19 infection is associated with peripheral immunometabolic alterations affecting neuroimmune responses in the hippocampus Abstract Fatigue is a common and disabling symptom reported following SARS-CoV-2 infection, yet the underlying biological mechanisms remain poorly...

SARS-CoV-2 spike-driven reactivation of latent herpesviruses as a mechanistic link to post-viral diseases Jana, Manoj K.; Nora-Krukle, Zaiga; Prusty, Bhupesh K. Significance Persistent symptoms following viral infections are increasingly recognized, yet the biological mechanisms driving...

CD4+ T cell signature in long COVID: insights from an unvaccinated cohort Abstract Objective: The pathogenesis of Long COVID (LC) remains poorly understood, with the analysis of immune responses often obscured by variables such as vaccination and reinfection. This study aimed to determine...

Agreement and reliability between the two-day 6-minute incremental step test and two-day cardiopulmonary exercise test in post COVID-19 condition for assessing post-exertional malaise: The REVEAL-study Abstract Background Post-Exertional Malaise (PEM) is a core symptom of post COVID-19...