mitochondria

  1. D

    Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers, Flockhart et al, 2021

    https://doi.org/10.1016/j.cmet.2021.02.017 "Exercise training positively affects metabolic health through increased mitochondrial oxidative capacity and improved glucose regulation and is the first line of treatment in several metabolic diseases. However, the upper limit of the amount of...
  2. Andy

    USP30 protects against oxygen-glucose deprivation/reperfusion induced [mito] fragmentation & ubiquitination & degradation of MFN2, Chen et al, 2021

    Full title: USP30 protects against oxygen-glucose deprivation/reperfusion induced mitochondrial fragmentation and ubiquitination and degradation of MFN2 Open access, https://www.aging-us.com/article/202629/text
  3. John Mac

    Dysregulated Provision of Oxidisable Substrates to the Mitochondria in ME/CFS Lymphoblasts, 2021, Missailidis et al

    https://www.mdpi.com/1422-0067/22/4/2046
    • John Mac
    • Thread
    • amino acid catabolism beta-oxidation fisher glycolysis me/cfs missailidis mitochondria proteomics tca cycle transcriptomics
    • Replies: 68
    • Forum: ME/CFS research
  4. John Mac

    A systematic review of nutraceutical interventions for mitochondrial dysfunctions in ME/CFS, 2021, Marshall-Gradisnik et al

    https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02742-4
    • John Mac
    • Thread
    • 2021 marshall-gradisnik mitochondria mitochondrial dysfunction nutraceutical review staines treatment
    • Replies: 3
    • Forum: ME/CFS research news
  5. Andy

    Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy, Irene Pila-Castellanos et al, 2021

    Open access, https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1009340
  6. Sly Saint

    Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples, Miller et al, 2021

    https://www.nature.com/articles/s41598-020-79552-z see also article about the research https://www.thailandmedical.news/news/covid-19-news-sars-cov-2-coronavirus-attacks-mitochondria,-the-power-house-of-cells-in-human-host-constant-fatigue-could-result-from-this
  7. leokitten

    The Artemisinin-Derived Autofluorescent Compound BG95 Exerts Strong Anticytomegaloviral Activity. Wild et al. Int J Mol Sci 2020

    Full title: The Artemisinin-Derived Autofluorescent Compound BG95 Exerts Strong Anticytomegaloviral Activity Based on a Mitochondrial Targeting Mechanism Another paper examining virus-induced mitochondrial fragmentation/fission in this case by HCMV and effects of an artesunate-derived...
    • leokitten
    • Thread
    • antiviral drugs artemisinin cytomegalovirus mitochondria mitochondrial architecture mitochondrial fragmentation mitochondrial function
    • Replies: 0
    • Forum: Other health news and research
  8. Sly Saint

    Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells : Herpich et al 2020

    https://www.sciencedirect.com/science/article/abs/pii/S0531556520305258?dgcid=rss_sd_all
  9. Trish

    Role of mitochondria, oxidative stress and the response to antioxidants in ME/CFS: a possible approach to SARS-CoV-2 ‘long-haulers’?, 2020, Tate et al

    Review article: Role of mitochondria, oxidative stress and the response to antioxidants in myalgic encephalomyelitis/chronic fatigue syndrome: a possible approach to SARS-CoV-2 ‘long-haulers’? EmilyWood, Katherine H.Hall, WarrenTate (University of Otago, New Zealand)...
    • Trish
    • Thread
    • 2020 antioxidants coq10 katherine hall long covid me/cfs mitochondria mitoq oxidative stress warren tate
    • Replies: 1
    • Forum: Long Covid research
  10. Andy

    Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress..., 2020, Wang et al

    Full title: Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population Open access, https://www.sciencedirect.com/science/article/pii/S2213231720309460
  11. Andy

    Preprint: Type I interferon potentiates metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice, 2020, Lei et al

    Open access, https://www.biorxiv.org/content/10.1101/2020.09.22.308171v1.full-text
  12. Andy

    Nrf2 deficiency induces skeletal muscle mitochondrial dysfunction: a proteomics/bioinformatics approach, 2020, Willis and Deane

    In mice. Open access PDF available at https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280758
  13. Kalliope

    Nature: SLC25A51 is a mammalian mitochondrial NAD+ transporter - 2020 - by Luongo et al

    SLC25A51 is a mammalian mitochondrial NAD+ transporter - Luongo et al Abstract Mitochondria require nicotinamide adenine dinucleotide (NAD+) in order to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD+ transporters have been...
  14. J

    Elevated Energy Production in Chronic Fatigue Syndrome Patients, Lawson et al. 2016

    https://pubmed.ncbi.nlm.nih.gov/27747291/ http://www.jnsci.org/files/article/2016/e221.pdf Thread. https://forums.phoenixrising.me/threads/elevated-energy-production-in-chronic-fatigue-syndrome-patients.47443/
  15. anciendaze

    Mitochondria have their own separate fatty acid synthesis mechanism

    This post on Phys.org just caught my eye. I didn't realize there was a distinct mitochondrial cycle for this essential part of cell metabolism. Here's the primary citation. This is the first I have heard of MEPAN and the foundation to study it. This devastating disease could be a key to the...
  16. Sly Saint

    A SWATH-MS analysis of ME/CFS peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction: Sweetman,Vallings,Tate et al Aug 2020

    A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction https://www.researchsquare.com/article/rs-52172/v1
    • Sly Saint
    • Thread
    • 2020 me/cfs metabolism mitochondria mitochondrial dysfunction paper peroxiredoxin proteomics ros vallings sweetman warren tate
    • Replies: 17
    • Forum: ME/CFS research
  17. InitialConditions

    Mitochondria May Hold Keys to Anxiety and Mental Health

    https://www.quantamagazine.org/mitochondria-may-hold-keys-to-anxiety-and-mental-health-20200810/ Research hints that the energy-generating organelles of cells may play a surprisingly pivotal role in mediating anxiety and depression.
  18. Indigophoton

    Attention and capacity limits in perception: A cellular metabolism account, Bruckmaier et al, 2020

    Saw this, thought of us. I'm not up to reading the paper (abstract and link below), so haven't assessed its quality, but the article in neuroscience news is interesting. Perhaps this sort of phenomenon might help to explain why an ME brain is particularly prone to falling over with too much...
  19. Sly Saint

    A systematic review of mitochondrial abnormalities in ME/CFS/systemic exertion intolerance disease, 2020, Holden et al.

    A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02452-3
    • Sly Saint
    • Thread
    • 2020 griffith university holden marshall-gradisnik me/cfs metabolomics mitochondria paper review staines
    • Replies: 6
    • Forum: ME/CFS research
  20. Cheshire

    A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia (2020) van Tilburg et al.

    https://pubmed.ncbi.nlm.nih.gov/32658146/ No idea if this is a promising lead or not, but here is a thread of one of the PIs explaining what they found
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