mitochondria

  1. anciendaze

    Mitochondria have their own separate fatty acid synthesis mechanism

    This post on Phys.org just caught my eye. I didn't realize there was a distinct mitochondrial cycle for this essential part of cell metabolism. Here's the primary citation. This is the first I have heard of MEPAN and the foundation to study it. This devastating disease could be a key to the...
  2. Sly Saint

    A SWATH-MS analysis of ME/CFS peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction: Sweetman,Vallings,Tate et al Aug 2020

    A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction https://www.researchsquare.com/article/rs-52172/v1
    • Sly Saint
    • Thread
    • 2020 me/cfs metabolism mitochondria mitochondrial dysfunction paper peroxiredoxin prdx6 proteomics ros vallings sweetman warren tate
    • Replies: 17
    • Forum: ME/CFS research
  3. InitialConditions

    Mitochondria May Hold Keys to Anxiety and Mental Health

    https://www.quantamagazine.org/mitochondria-may-hold-keys-to-anxiety-and-mental-health-20200810/ Research hints that the energy-generating organelles of cells may play a surprisingly pivotal role in mediating anxiety and depression.
  4. Indigophoton

    Attention and capacity limits in perception: A cellular metabolism account, Bruckmaier et al, 2020

    Saw this, thought of us. I'm not up to reading the paper (abstract and link below), so haven't assessed its quality, but the article in neuroscience news is interesting. Perhaps this sort of phenomenon might help to explain why an ME brain is particularly prone to falling over with too much...
  5. Sly Saint

    A systematic review of mitochondrial abnormalities in ME/CFS/systemic exertion intolerance disease, 2020, Holden et al.

    A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02452-3
    • Sly Saint
    • Thread
    • 2020 griffith university holden marshall-gradisnik me/cfs metabolomics mitochondria paper review staines
    • Replies: 6
    • Forum: ME/CFS research
  6. Cheshire

    A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia (2020) van Tilburg et al.

    https://pubmed.ncbi.nlm.nih.gov/32658146/ No idea if this is a promising lead or not, but here is a thread of one of the PIs explaining what they found
  7. J

    Mitochondrial protein interaction landscape of SS-31, 2020, Chavez et al.

    https://www.pnas.org/content/early/2020/06/16/2002250117 popular article here https://newsroom.uw.edu/news/study-yields-clues-how-drug-may-boost-aged-mitochondria
  8. Sly Saint

    Acute Phase Phospholipids Related to the Cardiolipin of Mitochondria in the Sera of Patients With CFS, ciguatera, GWI, 2008. Hokama et al

    Acute Phase Phospholipids Related to the Cardiolipin of Mitochondria in the Sera of Patients With Chronic Fatigue Syndrome (CFS), Chronic Ciguatera Fish Poisoning (CCFP), and Other Diseases Attributed to Chemicals, Gulf War, and Marine Toxins Yoshitsugi Hokama 1 , Cara Empey-Campora, Cynthia...
    • Sly Saint
    • Thread
    • 2008 cancer cardiolipin ciguatera gulf war illness me/cfs mitochondria paper phospholipids serum toxins
    • Replies: 3
    • Forum: ME/CFS research
  9. Kalliope

    Press release on Danish dissertation on mitochondrial dysfunction - defended by Ana C. Gonzalez Ebsen

    Press release from Aarhus University, Denmark (uploaded by the Danish ME Association). The press release is both in Danish and English. Title of dissertation: Mitocondrial dysfunction in an inborn error of metabolism and in patients with unexplained chronic fatigue. The aim of this PhD...
  10. Dolphin

    Mitochondria and Immunity in Chronic Fatigue Syndrome, 2020, Anderson & Maes

    Preprint https://www.researchgate.net/publication/339886499_Mitochondria_and_Immunity_in_Chronic_Fatigue_Syndrome Free full text...
    • Dolphin
    • Thread
    • 2020 anderson maes me/cfs mitochondria paper review
    • Replies: 3
    • Forum: ME/CFS research
  11. Kalliope

    Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in ME/CFS - 2020 - Schreiner

    by Philipp Schreiner, Thomas Harrer, Carmen Scheibenbogen, Stephanie Lamer, Andreas Schlosser, Robert K. Naviaux and Bhupesh K. Prusty Published in ImmunoHorizons Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multifactorial disorder with many possible triggers...
    • Kalliope
    • Thread
    • 2020 bhupesh prusty herpesvirus hhv-6 me/cfs mitochondria naviaux paper scheibenbogen schreiner
    • Replies: 136
    • Forum: ME/CFS research
  12. Andy

    Alternative substrate metabolism depends on cerebral metabolic state following traumatic brain injury, 2020, Greco et al

    In rats. Open access, https://www.sciencedirect.com/science/article/pii/S0014488620301205
  13. Dolphin

    Metabolic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome not due to anti-mitochondrial antibodies, 2020, Nilsson et al

    http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A1415500&dswid=9881
    • Dolphin
    • Thread
    • 2020 antibodies atp me/cfs mitochondria nilsson paper pyruvate dehydrogenase complex sweden
    • Replies: 5
    • Forum: ME/CFS research
  14. Sly Saint

    Event: Mitochondria Day - by Biolab Medical Unit - Apr 24 2020

    https://www.eventbrite.co.uk/e/mitochondria-day-tickets-61684068710
  15. Sean

    A cnidarian parasite of salmon (Myxozoa: Henneguya) lacks a mitochondrial genome (2020). Yahalomi D, et al

    Not strictly health news, but an interesting development in understanding the role of mitochondria. "The myxozoan cells retain structures deemed mitochondrion-related organelles, but have lost genes related to aerobic respiration and mitochondrial genome replication. Our discovery shows that...
  16. Sly Saint

    Cell-Based Blood Biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Missailidis et al Feb 2020

    https://www.preprints.org/manuscript/202002.0029/v1
    • Sly Saint
    • Thread
    • australia biomarker blood fisher lymphocytes me/cfs missailidis mitochondria mtor
    • Replies: 26
    • Forum: ME/CFS research
  17. Andy

    Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function..., 2020, Anderson and Maes

    Full title: Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via Suboptimal Mitochondrial Function: Assessment, Treatment and Classification Implications Paywall, http://www.eurekaselect.com/178870/article Not available via Sci hub at time of posting.
    • Andy
    • Thread
    • 2020 butyrate dysbiosis gut microbiome leaky gut maes microbiome mitochondria mitochondrial dysfunction paper
    • Replies: 0
    • Forum: Other health news and research
  18. Sly Saint

    Perspective: Cell Danger Response Biology—The New Science that Connects Environmental Health with Mitochondria and the Rising Tide of Chronic Illness

    Perspective: Cell Danger Response Biology—The New Science that Connects Environmental Health with Mitochondria and the Rising Tide of Chronic Illness Robert K Naviaux Dec 2019 https://www.sciencedirect.com/science/article/pii/S1567724919302922
  19. Sly Saint

    Mitochondria are the “canary in the coal mine” for cellular stress - Salk Researchers Dec 2019

    full article here https://www.salk.edu/news-release/mitochondria-are-the-canary-in-the-coal-mine-for-cellular-stress/
  20. MyalgicE

    Mitochondrial stress causes neuronal dysfunction via an ATF4-dependent increase in L-2-hydroxyglutarate (2019) Hunt et al

    Abstract Mitochondrial stress contributes to a range of neurological diseases. Mitonuclear signaling pathways triggered by mitochondrial stress remodel cellular physiology and metabolism. How these signaling mechanisms contribute to neuronal dysfunction and disease is poorly understood. We find...
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