pace trial

preprint https://www.medrxiv.org/content/10.1101/2021.01.25.21250436v1 https://www.medrxiv.org/content/10.1101/2021.01.25.21250436v1.full.pdf

Good intentions regularly lead to terrible outcomes. While researchers’ hearts may be pure, that fact alone does not guarantee that their works will be blessed. In psychology, we sometimes talk about the “just-world fallacy”, the belief that in the end our collective actions will average out...

https://www.youtube.com/watch?v=2hrPnK1OWXQ

David Tuller: Trio of Trials Shows Limits of CBT for Medically Unexplained Symptoms https://www.virology.ws/2020/06/17/trial-by-error-trio-of-trials-shows-limits-of-cbt-for-medically-unexplained-symptoms/

Not sure if this deserves it's own thread or should be folded into the PACE thread as it's based on PACE trial data. Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0022399919310323 Sci hub, https://sci-hub.tw/10.1016/j.jpsychores.2020.110154

There are several diagnostic criteria for ME which complicates research and hinders the development of safe and effective treatments. Broad criteria for ME results in misdiagnosis and incorrect treatment. Researchers need stricter criteria [1]. Misdiagnosis is common, 40% of patients diagnosed...

The PACE trial evaluated Graded Exercise (GET) Therapy and Cognitive Behavioural Therapy (CBT) as treatments for ME. Exercise as treatment seems counterintuitive when even minimal mental or physical exertion leads to a worsening of symptoms and reduced function [1]. The defining symptom of ME is...

Interesting article I had not seen before; features Len Jason, PACE trial, David Tuller, Mary Dimmock, Wessely, White, Esther Crawley, Steven Holgate, Jo Edwards and more. just pop this bit in here o_O https://goodmenproject.com/the-good-life/worklife-balance/fighting-over-fatigue/

https://www.tandfonline.com/doi/abs/10.1080/21641846.2017.1299358 Free full text: https://www.researchgate.net/publication/315482747_PACE_trial_claims_of_recovery_are_not_justified_by_the_data_A_Rejoinder_to_Sharpe_Chalder_Johnson_Goldsmith_and_White_2017

CFS/ME National Services Survey Feb 2018 Snap shot audit BACME National Services Workstream Report Published March 2019 https://www.bacme.info/sites/bacme.info/files/BACME CFS ME National services survey March19.pdf

http://www.virology.ws/2019/12/31/trial-by-error-my-2011-exchange-with-white-et-al-about-case-definition/

Useful resource. built in search facility http://www.margaretwilliams.me/

Have been going thro this. http://www.bcwomens.ca/health-professionals/professional-resources/complex-chronic-diseases Clinical Protocol http://www.bcwomens.ca/Specialized-Services-Site/Documents/Complex%20Chronic%20Diseases%20%28CCDP%29/Clinical%20Protocol-ME-CFS.pdf

It is not needed to go to third parties analysis to find the glaring errors. Quoting something I wrote for other purposes. The PACE trial was the largest trial into CBT/GET/APT as a proposed treatment for CFS/ME. The authors of this trial later released Adaptive pacing, cognitive behaviour...

http://voicesfromtheshadowsfilm.co.uk/2018/dialogues-for-a-neglected-illness-a-new-mecfs-project-awarded-wellcome-funding/

Hello all, I am very familiar with the ICC, CC, CDC vs Oxford criteria discussion, prevalence differences, Oxford obfuscation, etc. but I have a very specific question about what the Wessely crew mean by "CF" vs "CFS". This is not merely academic and is of consequence for important ongoing...

Half the research spending for ME in a 10 year period in the UK went on the widely discredited £5M PACE trial [1]. The trial is taught in textbooks [2] and universities [3] as an example of how not to conduct a clinical trial. Over 100 experts and 80 charities want an independent review [4] and...

Hi everyone, A prominent Dutch psychiatrist Bram Bakker has written a book where he published a critical chapter about PACE, CBT/GET and pro Mark Vink. I can't post the whole chapter here but it would be great if you could help me retweet the quote I posted so it gets the attention it needs...

https://www.meassociation.org.uk/2019/08/my-daughter-and-the-pervasive-dangers-of-pace-in-paediatric-m-e-by-adam-johnson-06-august-2019/