Covid-19 vaccines and vaccinations

Wonko said:
Why would you think that?

Have you got the results of a test that shows that any of the vaccine shots I was given 'took'?

Coz I haven't, coz the NHS hasn't given me any such tests.

The way I see it, my chances of getting seriously ill and needing hospital treatment, are either 100%, or 0% - with my having no way of determining which it is.

On the one hand most here seem to accept that not all people are identical, and on the other, just coz many people (not all people, triple vac'd people would still appear to still be dying from covid in the UK) seem to think that covid will no longer make anyone who has been vaccinated seriously ill.
Click to expand...

I certainly have doubts that vaccines are effective in terms of the individual but I'm content that they work at a group/population level i.e. reduce the risk of serious illness or death ---. If they aren't effective at a group/population level then Governments shouldn't/wouldn't fund them. But yes, I limit my contacts because I live with someone with an underlying health condition --- I'm not reassured the vaccine would prevent serious illness//death in their case --- there are still vaccinated people dying, just less of them (compared to the unvaccinated community).
 
Last edited:
There are too many reports of ME/CFS patients getting much worse with Covid (myself included in that) to really suggest to do anything but avoid infection. I remain mighty disappointed in the JVCI's passing of the buck on priority for vaccinations again this autumn onto GPs. There are plenty of reports and papers showing worsening condition for existing Long haulers and ME/CFS patients when catching Covid again with increasing chance of severe problems. On the other hand does the vaccination even really work in these patients groups? As far as I know they never tested, paid little attention to the impact of the vaccines on these groups calling all those with side effects as anti vaxxers and moved on. All I know is we don't know and no one is testing nor is anyone interested in determining if as a group the vaccine works or is harmful for us in particular.
 
Mij said:
Wouldn't an inhaled aerosol vaccine be more effective to target the lungs and upper airway than a intranasal vaccine?
Click to expand...

Hypothetically, but it depends on sufficient antigen dosage and B-cell/follicular dendritic cell response in germinal centres in the lymph. Perhaps viral vector vaccines will work better than live attenuated virus vaccines. But viral vector vaccines tend to rely on transfecting regular dendritic cells, which results in a strong T-cell response, but the antigen has to exit the cell and captured by follicular dendritic cells somehow (and in turn presented or preserved over time for later presentation to B-cells).
 
Last edited:
Researchers have identified antibodies that may make coronavirus vaccines unnecessary.

A scientific breakthrough by Tel Aviv University: A team of researchers from the university has demonstrated that antibodies isolated from the immune system of recovered COVID-19 patients are effective in neutralizing all known strains of the virus, including the Delta and the Omicron variants. According to the researchers, this discovery may eliminate the need for repeated booster vaccinations and strengthen the immune system of populations at risk.

Researchers have identified antibodies that m | EurekAlert!
 
Mij said:
Researchers have identified antibodies that may make coronavirus vaccines unnecessary.

A scientific breakthrough by Tel Aviv University: A team of researchers from the university has demonstrated that antibodies isolated from the immune system of recovered COVID-19 patients are effective in neutralizing all known strains of the virus, including the Delta and the Omicron variants. According to the researchers, this discovery may eliminate the need for repeated booster vaccinations and strengthen the immune system of populations at risk.

Researchers have identified antibodies that m | EurekAlert!
Click to expand...

I bet the pharma companies won't be happy about that. It will cut off one of their many lucrative revenue sources.
 
Mij said:
Researchers have identified antibodies that may make coronavirus vaccines unnecessary.

A scientific breakthrough by Tel Aviv University: A team of researchers from the university has demonstrated that antibodies isolated from the immune system of recovered COVID-19 patients are effective in neutralizing all known strains of the virus, including the Delta and the Omicron variants. According to the researchers, this discovery may eliminate the need for repeated booster vaccinations and strengthen the immune system of populations at risk.

Researchers have identified antibodies that m | EurekAlert!
Click to expand...

Haven't read it but where do the antibodies come from - people who have been infected?
If the antibodies work then that might be useful in treating those who are at risk of serious illness --- those who are hospitalised,---
 
@FMMM1

In the article I posted it says:

antibodies isolated from the immune system of recovered COVID-19 patients are effective in neutralizing all known strains of the virus, including Delta and Omicron variants.
 
Trish said:
Each new variant vaccine needs to be developed, manufactured, tested and distributed, and with Covid changing so rapidly it will inevitably have mutated again.
Click to expand...

Yes, about that —

Pfizer and Moderna have only submitted mouse data for the BA.4/BA.5 boosters. Although not released publicly, Pfizer shared preliminary findings at a June FDA advisory meeting; the findings included eight mice that were given the BA.4/BA.5 booster as their third dose. Those mice, compared with the mice given the original vaccine, showed an increased antibody response to all Omicron variants tested.
Click to expand...

https://www.yalemedicine.org/news/omicron-booster-covid-19
 
Trish said:
Each new variant vaccine needs to be developed, manufactured, tested and distributed, and with Covid changing so rapidly it will inevitably have mutated again.
Click to expand...

That testing doesn't require long and complex clinical trials though. The testing is more akin to quality control.

The changes between vaccines are smaller than that of changes between annual Influenza vaccines - and as such they could be manufactured far quicker than currently, so long as health authorities actually commit to it.
 
I'm frustrated that the most prominent American politician said the pandemic is over on Sixty Minutes. He qualified that somewhat by saying there's still a lot more work to be done, but many people will focus only on his saying it's over. Congress was already resisting approving additional funds for more testing and vaccinations, so this gives certain members more cover for denying this much needed funding.

I think he was trying to offer encouragement after what we've all been through since 2020, but with around 420 Americans are dying daily from covid-related illnesses and so many getting long-term health problems from the virus, downplaying the severity of covid is the very last thing we should be doing. Anyway, it really shouldn't be a politician who announces the pandemic is over.
 
We have finally made it for my daughter's first vaccination.
She decided to go ahead last summer but health declined and GPs were no longer offering at home visits .

Health is not brilliant but a bit more stable and medical consultations now starting to come through, so she booked up herself ( a big thing in itself)

Sitting in post Jag waiting area ( having lowered average age by about 40 years) watching a queue of mainly pensioners without masks in an indoor foyer with not brilliant ventilation , and one healthcare worker almost using her mask as a chinstrap.

Over 2 years in ....
 
Merged thread

Moderna COVID-19 Booster Likely Triggers Acquired Angioedema

https://angioedemanews.com/news/covid-19-booster-vaccine-trigger-of-acquired-angioedema/

===

p.s.

i have angioedema, with usual angioedema features, triggered by extremely small amounts of a specific, very common substance touching the skin anywhere. the touched location seems unrelated to where the angioedema reactions occur. the reactions are delayed.

c1-inh appears to be normal and the "take very large quantities of antihistamine for a very long time" test recommended in uptodate comes back as it's non-histaminergic [despite me having allergic/mcas features that seem urelated to the angioedema].

idk what subtype of angioedema this is or what the cause is, and the specific substance is not mentioned online or in uptodate as a trigger that i can find, all of the differential diagnoses are clearly very different and angioedema is the only match.
 
Last edited by a moderator:
“It is most likely that the vaccine triggered an acute event in a patient who already had clinical manifestations of AAE,” the researchers wrote.

“Physicians examining patients who are to undergo SARS Cov-2 vaccinations should also take into account these less common symptoms and refer patients for further investigation in order to make a correct diagnosis,” they added.
Click to expand...

The reaction occurred 72 hours after the vaccination. It's hard to know in this case if the swelling around the throat would have happened without the vaccination, given the past episodes of upper limb swelling. More likely, perhaps it would have been triggered by any immunological challenge - in this case it was a vaccination but if the man had not had the vaccination, perhaps it would have happened when he next got a cold or something.
 
You must log in or register to reply here.
Back
Top Bottom