Covid-19 vaccines and vaccinations

vEidence that the time of the day of vaccine administration influences the adaptive immune response

Influence of circadian clocks and adaptive immunity and vaccination responses, 2023, Louise Madeleine Ince et al

Abstract
The adaptive immune response is under circadian control, yet, why adaptive immune reactions continue to exhibit circadian changes over long periods of time is unknown. Using a combination of experimental and mathematical modeling approaches, we show here that dendritic cells migrate from the skin to the draining lymph node in a time-of-day-dependent manner, which provides an enhanced likelihood for functional interactions with T cells. Rhythmic expression of TNF in the draining lymph node enhances BMAL1-controlled ICAM-1 expression in high endothelial venules, resulting in lymphocyte infiltration and lymph node expansion. Lymph node cellularity continues to be different for weeks after the initial time-of-day-dependent challenge, which governs the immune response to vaccinations directed against Hepatitis A virus as well as SARS-CoV-2.

In this work, we present a mechanistic understanding of the time-of-day dependent development and maintenance of an adaptive immune response, providing a strategy for using time-of-day to optimize vaccination regimes.

https://www.nature.com/articles/s41467-023-35979-2






 
Mij said:
vEidence that the time of the day of vaccine administration influences the adaptive immune response

Influence of circadian clocks and adaptive immunity and vaccination responses, 2023, Louise Madeleine Ince et al

Abstract
The adaptive immune response is under circadian control, yet, why adaptive immune reactions continue to exhibit circadian changes over long periods of time is unknown. Using a combination of experimental and mathematical modeling approaches, we show here that dendritic cells migrate from the skin to the draining lymph node in a time-of-day-dependent manner, which provides an enhanced likelihood for functional interactions with T cells. Rhythmic expression of TNF in the draining lymph node enhances BMAL1-controlled ICAM-1 expression in high endothelial venules, resulting in lymphocyte infiltration and lymph node expansion. Lymph node cellularity continues to be different for weeks after the initial time-of-day-dependent challenge, which governs the immune response to vaccinations directed against Hepatitis A virus as well as SARS-CoV-2.

In this work, we present a mechanistic understanding of the time-of-day dependent development and maintenance of an adaptive immune response, providing a strategy for using time-of-day to optimize vaccination regimes.

https://www.nature.com/articles/s41467-023-35979-2
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So what time of day is it saying is best to get vaccinated? i cant pick out the key point through all that information
 
I think it was done in mice. They like their vaccinations before breakfast so they can do a bit of scratching. I personally like a vaccination either at 11.30 am so that I can get home for lunch before it starts to itch - or just before tea time.

I can't see health services going in for the idea that when there is a pandemic everyone should be vaccinated at 9.45 precisely. Seems a bit daft to me.
 
About a month ago which was 14 months after my third vaccine, I experienced a mild electric shock sensation in the back of my right leg, never experienced before. It has been followed by intermittent mild tingling in both lower legs, never experienced before.

It seems a long time after vacc for a symptom ( assuming that this is what it is - a neuropathy) to develop.
 
Binkie4 said:
About a month ago which was 14 months after my third vaccine, I experienced a mild electric shock sensation in the back of my right leg, never experienced before. It has been followed by intermittent mild tingling in both lower legs, never experienced before.

It seems a long time after vacc for a symptom ( assuming that this is what it is - a neuropathy) to develop.
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Fourteen months later seems rather late for an adverse reaction to a vaccine.
 
TigerLilea said:
Fourteen months later seems rather late for an adverse reaction to a vaccine.
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I agree. Nothing like the earlier responses which were minutes after vaccination.
For me, one of the effects of an extreme response to the vaccine has been a loss of confidence in my body, in how I will react to perfectly ordinary things. I did take the flu vaccine this winter as I have for many winters but I was very frightened. Next week I am to have a medical procedure under radiographic guidance and again I am very nervous. Rather than assuming my body will just deal with it as I did before these events, I am anxious about what is happening and how I will react, about whether something unexpected will happen. I do find it difficult.
 
Covid: Last chance for adults under 50 to get booster
4 February 2023
https://www.bbc.co.uk/news/health-64496025
Adults under 50 in England have just over a week left to take up the NHS offer of a Covid booster jab.

It is the last opportunity for healthy 16-49-year-olds to get a top-up dose - if they have not yet had three jabs.

The vaccine can help protect against severe illness, even if you have caught Covid before.

Appointments are available at thousands of different sites, including GP practices and high street pharmacies, up to and including Sunday 12 February.

Anyone aged 16 or over - or an at-risk child aged 12 to 15 - who has had both primary jabs, qualify for this booster, which has been available for more than a year.

So far, 15,000 people have booked in for next week and there are still 391,000 appointments available, says NHS England.
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https://www.news-medical.net/news/2...r8mpNShviWyiawQ0PntEDhNbOMe_ELLxk1LvKMhKfAkJA

"In a recent study published in Pathogens, researchers discussed the safety of coronavirus disease 2019 (COVID-19) vaccines in healthy people and patients with autoimmunity or cardiac issues."

Conclusion
Taken together, the authors discussed COVID-19 vaccine safety and associated adverse events. The scientific community must determine whether the existing nucleic acid-based vaccines should be continued for at-risk individuals with autoimmunity when the long-term effects of vaccination are unclear (in these sub-populations). The development of COVID-19 vaccines using conventional technologies may be desirable for older adults and at-risk individuals.




I hope this work is done quickly so that consent for the vaccine can be as informed as possible. As someone with both autoimmune and cardiac issues now advised to take no further vaccine, I know I have been exposed to risk in taking the existing covid 19 vaccines. I would have been exposed to risk too had I not taken them: I recognise that. With my adverse effects still ongoing, I would wish for swift developments so that more accurate information can be given re risk at the time of giving consent, and safer alternatives to the current vaccines be developed for those at risk.
 
Autoimmunity is not generally a risk factor for problems with vaccines as far as I am aware. This article appeared in an obscure journal and may be written by people either with no real expertise or with preconceived ideas.

Apart from anything else I am not sure that there is any evidence regarding this new type of vaccine anyway - so it sounds like idle speculation at least from he abstract.
 
Binkie4 said:
I hope this work is done quickly so that consent for the vaccine can be as informed as possible. As someone with both autoimmune and cardiac issues now advised to take no further vaccine, I know I have been exposed to risk in taking the existing covid 19 vaccines. I would have been exposed to risk too had I not taken them: I recognise that. With my adverse effects still ongoing, I would wish for swift developments so that more accurate information can be given re risk at the time of giving consent, and safer alternatives to the current vaccines be developed for those at risk.
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I can't have any more vaccines either. Before the covid vaccines I'd never ever had a problem with vaccines.
 
TigerLilea said:
I can't have any more vaccines either. Before the covid vaccines I'd never ever had a problem with vaccines.
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Just to add confusion; over the Millennium New Year I had a bad dose of flue (virus not formally confirmed) which triggered a major relapse in my ME. In the years following that the flue jab would knock me out for three weeks each time I had it, so after several years I stopped having it as I had then had to take ill health retirement and generally could avoid people with flue/colds and avoid others if I was worried I might have a bug.

In contrast I have had no adverse effects from the Covid jabs after the first few days and have now restarted the flue jab with no noticeable effects at all.

(Added - Part of the variation of ME. I have had periods when I seem to get every bug going, and periods where I never seem to catch anything, though often it is not possible to distinguish PEM from a mild infection that doesn’t seem to fully develop. So I guess if we have only ME, it is a matter of trying to guess if we are in the group likely to respond badly to vaccines or the group that is OK with them, and it is possible over time we could switch between groups. Yet another aspect of the natural history of ME that has not been described adequately.)
 
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Guillain-Barre syndrome following COVID-19 vaccines: A review of literature.

Objective: This study aimed to retrospectively analyze reported Guillain–Barré syndrome (GBS) cases that occurred after COVID-19 vaccination.

Methods: Case reports of GBS following COVID-19 vaccination that were published before May 14, 2022, were retrieved from PubMed. The cases were retrospectively analyzed for their basic characteristics, vaccine types, the number of vaccination doses before onset, clinical manifestations, laboratory test results, neurophysiological examination results, treatment, and prognosis.

Results: Retrospective analysis of 60 case reports revealed that post-COVID-19 vaccination GBS occurred mostly after the first dose of the vaccination (54 cases, 90%) and was common for DNA vaccination (38 cases, 63%), common in middle-aged and elderly people (mean age: 54.5 years), and also common in men (36 cases, 60%). The mean time from vaccination to onset was 12.3 days. The classical GBS (31 cases, 52%) was the major clinical classification and the AIDP subtype (37 cases, 71%) was the major neurophysiological subtype, but the positive rate of anti-ganglioside antibodies was low (7 cases, 20%). Bilateral facial nerve palsy (76% vs 18%) and facial palsy with distal paresthesia (38% vs 5%) were more common for DNA vaccination than for RNA vaccination.

Conclusion: After reviewing the literature, we proposed a possible association between the risk of GBS and the first dose of the COVID-19 vaccines, especially DNA vaccines. The higher rate of facial involvement and a lower positive rate of anti-ganglioside antibodies may be a characteristic feature of GBS following COVID-19 vaccination. The causal relationship between GBS and COVID-19 vaccination remains speculative, more research is needed to establish an association between GBS and COVID-19 vaccination. We recommend surveillance for GBS following vaccination, because it is important in determining the true incidence of GBS following COVID-19 vaccination, as well as in the development of a more safer vaccine.

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1078197/full
 
Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets (2022)

... image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer-BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet-leukocyte interaction was insignificant.
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Compensation denied to hundreds of Covid vaccine victims suffering 'severe' side effects

URGENT research is needed to investigate adverse vaccine reactions but institutions fear rocking the boat, say scientists. They believe the issue has become so politicised they are increasingly reluctant to ask questions. It comes as hundreds of people who became seriously ill after having the Covid-19 jab have found themselves locked out of the Vaccine Damage Payment Scheme. They are backed by the Daily Express Justice for Jab Victims campaign and politicians including Tory MP Danny Kruger.
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Compensation denied to hundreds of Covid vaccine victims suffering 'severe' side effects (msn.com)
 
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