Daridorexant - treatment for insomnia

[Braganca]

I had tried this back in 2024 and couldn’t tolerate the side effects, also found it not helpful for sleep. Decided to give it another go. Went very slowly — halved the 25mg pill and took 12.5mg for 10 days. Increased to 25mg for 10 days. Then up to 37.5 (1.5 25mg pills). Each time I raised dose I’d have worse grogginess and brain fog during day. And sleep would work for one or two nights and then not. Stuck with it, now after a month, no daytime grogginess and — I turn out light and just fall asleep like a normal person. Sleep about 8 hours which is amazing. Don’t feel any better ME wise during day — was hoping the extra or deeper sleep might improve cognition — not so far.

 

[Wits_End]

Sounds like another of those cases where ME patients need to come in at a lower than standard dose and then increase more slowly than normal. I wonder how often this does actually happen with ME? Seems to be a lot.

 

[neophyte32]

I've always been a very good sleeper, even after late-night exercise or intense work stress. The MECFS has ruined my sleep. At first, when it was mild to moderate, I would wake up at 3:30 or 4:00 AM and fall back asleep 1 or 2 hours later. Since the severe symptoms, I take 50 mg of Daridorexant and a small dose of benzodiazepine to help me sleep. Despite this, I still wake up 10 times a night.