Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

I think it's possible that if their algorithm is working very differently from the method the Biobank used, the effect size wouldn't be large enough to cross the significance threshold.

Another reason CFS might not have shown up but depression did could be that there are many more cases of depression in the Biobank which would increase statistical power. Using the Biobank search tool, I see 10 times as many depression cases as CFS cases:

Chronic Fatigue Syndrome - 2,017 cases
Depression - 26,114 cases

 

This might be a silly question, but what happens if there is overlap in participants between the cohorts in genetic studies?

Could you end up trying to validate your findings on a cohort that partially includes the people you first analysed?

 

On the subject of DecodeME, @Andy @Jonathan Edwards

Can you provide any update on when DecodeME is due to publish? Or is it still 'as soon as it's ready and hopefully before August'?

 

Something like that.

 

Yep, exactly that.

 

What is Precision Life and what is Beentjes, please?

 

All one word, 'PrecisionLife' - here's a thread on it.

 

NAD as in the coenzyme Nicotinamide adenine dinucleotide, or are you referring to a gene called NAD?

 

What's SequenceME? I have been fairly out of the loop.

 

I assume the former—NAMPT was one of the top genes identified, which is involved in an NAD production pathway

 

Beentjes is the preprint "Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity":

MedRxiv link | S4ME thread

SequenceME is a proposed long-read genetics study:

https://s4me.info/threads/sequencem...versity-of-edinburgh-and-action-for-me.41663/

 

Thread here.

 

10-item thread from one of the authors
https://threadreaderapp.com/thread/1912599009803333935.html