News From Jarred Younger / Neuroinflammation, Pain, and Fatigue Laboratory at UAB, From Aug 2020

mango said:
"A new study identifies a key brain region for upregulating and downregulating inflammation. This site presents a new target for inflammatory and neuroinflammatory diseases. The paper is open-access and available here: https://www.nature.com/articles/s41586-024-07469-y

- Jarred Younger"

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Here is that brain stem again. I wonder how he is going to reconcile the brain stem with microglia. We don't need both to explain ME/CFS; we just need either hypersensitive brain stem or hypersensitive microglia. It's hard to imagine it is microglia in some cases (like infection) and brain stem in other cases (like CCI).

I'm still leaning towards microglia. If the "thermostat" is broken, the resulting (inflammation) temperature should deviate from the norm. But we don't see that in ME/CFS. We only see the afferent temperature signal knocking out the patient w/o the resulting temperature change.
 
"It is a little-known fact that chronic inflammation causes depressed mood. I want to show you where in the brain this occurs, and why it makes no sense to tell someone with FM, ME/CFS, GWI, MCAS, or other chronic conditions that they "are just depressed". - Jarred Younger"

 
"Many people are concerned about the loss of their sense of smell that persists long after a SARS-CoV-2 infection. I want to explain how this anosmia occurs, and how it likely resolves over time. - Jarred Younger"

 
"028 - New findings: more evidence of poor oxygen perfusion in the brain.

We seeing high levels of lactate and low levels of choline in the brains of Gulf War Illness sufferers. This quick update covers our new analyses and why the may be important to those with chronic pain, fatigue, and cognitive issues. - Jarred Younger"

 
mango said:
"027 - New lab results - low brain oxygen in chronic disease

Here are brand new results from a recent brain study we conducted. We found reduced oxygen circulation in the brains of people with Gulf War Illness. We are also analyzing individuals with ME/CFS and fibromyalgia.

You can find the 7 Tesla brain images at: https://histopath.nmr.mgh.harvard.edu

Jarred Younger"

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Will be nice whenever the ME/CFS results for this are shown. Sounds like he's done the scans already.
 
029 - We need research on severe ME/CFS now

"25% of myalgic encephalomyelitis (ME/CFS) sufferers reported being homebound, and 4% report being bedridden. Research is urgently needed to better understand these severe cases of ME/CFS.

Below are links to the two open-access articles I mention in the video:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535418/

https://www.mdpi.com/2227-9032/9/2/106

- Jarred Younger"



ETA: He says he'll return to the oxygen perfusion data in next week's video.
 
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mango said:
029 - We need research on severe ME/CFS now

"25% of myalgic encephalomyelitis (ME/CFS) sufferers reported being homebound, and 4% report being bedridden. Research is urgently needed to better understand these severe cases of ME/CFS.

Below are links to the two open-access articles I mention in the video:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8535418/

https://www.mdpi.com/2227-9032/9/2/106

- Jarred Younger"



ETA: He says he'll return to the oxygen perfusion data in next week's video.
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He's not wrong.
I wonder if anyone will rise to the challenge (and be able to extract money from funders for it)
 
"030 - Does ME/CFS involve low brain oxygen?

Some brand new data from my lab using a cerebral perfusion scan to detect low brain oxygen. This scan is being used to determine (or rule out) poor brain oxygen in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

- Jarred Younger"

 
"031 - Air Quality Can Affect Chronic Fatigue and Pain

Here are some new results from our lab showing poor air quality may increase ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome) fatigue and pain. This report is being prepared by graduate student Chloe Jones and is being submitted for peer-review now. - Jarred Younger"

 
"The annual Stanford ME/CFS Working Group meeting concluded last week. In this meeting, researchers were able to share their preliminary results before public release. In this video, I give my observations on the state of the science. - Jarred Younger"
 
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