Open Medicine Foundation (OMF)

[V.R.T.]

Underpowered studies have been suggesting possible biomarkers, so it will be good to get a decent sized study to attempt to replicate those findings. The devil will be in the detail of course

Presumably they will have to look for finding see if they are there replicable though. So I guess I'd like more transparency on what findings they are trying to replicate.

It would be a shame for them not to look for a really important/interesting finding.

 

[Kitty]

I'm much more likely to donate if there is clear concise information on past, current and future projects and how funds are allocated.

Yep! Plus, I'm only likely to make repeat donations to charities that offer a clearly displayed opt-out on all further communication, right from the outset.

If I wanted to read their news I'd visit their website, and if I had spare cash I'd donate. In the meantime they should assume I don't have anything to give, or I don't want to be bugged, or both.

 

[Mij]

November 18, 2025

An Interview with Jonas Bergquist, MD, PhD, and Alain Moreau PhD

The Heart of the Matter
In an interview with Dr. Jonas Bergquist and Dr. Alain Moreau, two of OMF’s Directors, they talk about their main ideas behind ME/CFS, including an immune system that is too active in the brain and spinal cord, inherited factors, and how genes are expressed.

They then discuss connections between their research:

Moreau’s work found that a protein called SMPDL3B is different in people with ME/CFS. That protein can change cell membrane fluidity and influence a signaling pathway. These changes help contribute to the inflammation markers that Dr. Bergquist has found.

Dr. Bergquist measures the activity of a type of immune cell called microglia to identify inflammation in the nervous system. Microglia activity can be influenced by the protein haptoglobin and the hormone FGF-21. Dr. Moreau has found that these two molecules play a role in ME/CFS.

 

[Nightsong]

Via OMF - an interview with @MelbME and Wenzhong Xiao: