pem

I read an account by a housebound ME patient about being able to handle very short car trips as a passenger, while longer ones flare their symptoms even though they remain as idle as possible. Such a flare could only plausibly be induced by sensory stimuli during the trip, among which vehicle...

Video: Fatigue, Pacing and PEM Management | Lessons from ME/CFS - With Dr Ben Marsh I know this video has been mentioned on another thread but I think it might have been missed by many and deserves a thread of its own. In Episode 3 of our expert interviews series, Dr Asad Khan talks to Dr Ben...

Preprint Abstract Purpose: People living with long COVID describe a high symptom burden, and a more detailed assessment of chronic fatigue and post-exertional malaise (PEM) may inform the development of rehabilitation recommendations. The aims of this study were to use validated questionnaires...

Abstract Aims: Post-exertional malaise (PEM) is poorly understood in Gulf War Illness (GWI). Exercise challenges have emerged as stimuli to study PEM; however, little attention has been paid to unique cardiorespiratory and perceptual responses during exercise. This study tested whether select...

Abstract Post-exertional malaise (PEM), the key feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is characterized by baseline symptom exacerbation after exposure to a stressor, and some patients can experience new or non-typical symptoms. We hypothesized that new or...

Abstract Post-exertional malaise (PEM) is regarded as the hallmark symptom in chronic fatigue syndrome (CFS). The aim of the current study is to explore differences in CFS patients with and without PEM in indicators of aortic stiffness, autonomic nervous system function, and severity of...

https://creakyjoints.org/about-arthritis/rheumatoid-arthritis/ra-patient-perspectives/what-malaise-feels-like-rheumatoid-arthritis/ (I had not seen this decription used in relation to RA before. It reads more like an ME patient)

Background Post-exertional malaise (PEM) is a defining characteristic of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) but there is insufficient research dissecting the nature of PEM from the patients’ perspective. Methods A PEM questionnaire administered to 150 ME/CFS patients...

Not yet recruiting https://www.medifind.com/conditions/chronic-fatigue-syndrome/1135/clinical-trial/223304133

Effects of Post-Exertional Malaise on Markers of Arterial Stiffness in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome https://www.mdpi.com/1660-4601/18/5/2366/htm

https://www.centerwatch.com/clinical-trials/listings/225957/analysis-of-post-exertional-malaise-using-a-two-day-cpet-in-people-with-mecfs/?&radius=50&query=chronic-fatigue-syndrome&smt=true

https://www.researchsquare.com/article/rs-154011/v1

https://www.jns-journal.com/article/S0022-510X(21)00019-8/fulltext

In another thread, I noted that swimming leads to a difference balance in motor unit recruitment compared to land based activities and tends to favour a much greater rate of oxygen consumption for a given heart rate. I was not much of a swimmer when I was young and haven't picked it up since as...

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02683-4

https://www.mdpi.com/2077-0383/9/12/4040/htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703497/

PEM has become a mandatory symptom in many CFS guidelines, so I would expect that there is plenty of data of monitored patients during the malaise/fatigue interval because this is when the disease's mechanism of action is amplified and certain biomarkers should stick out and be clearer. Maybe...

https://www.tandfonline.com/doi/abs/10.1080/21641846.2020.1845287

I have spent some time (probably far too much for my health) drafting and redrafting this letter with some helpful suggestions from members on a members only thread: https://www.s4me.info/threads/draft-letter-to-the-authors-of-the-nih-pem-study-2020.17052/ The letter refers to a paper discussed...