Covid-19 vaccines and vaccinations

MeSci said:
Merged thread

A new Covid vaccine has been approved for use in the UK by regulators.

It is manufactured by Valneva, using more traditional technology - similar to how polio and flu shots are made.

It contains a whole copy of the virus which has been inactivated, so that it can't cause the disease but does teach the body how to fight it.

The UK was due to receive 100 million doses of the jab, but the government cancelled the deal in September due to a "breach of obligations".

The French company strenuously denied the government's accusation.

Dr June Raine, chief executive of the UK's Medicines and Healthcare products Regulatory Agency, said the approval followed "a rigorous review of the safety, quality and effectiveness of this vaccine".

Valneva Covid vaccine approved for use in UK - BBC News
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Inactivated viral vaccines tend to have poorer efficacy, against symptomatic infection (which relies on antibodies binding to the receptor binding domain(s) of the spike protein).

But there is an advantage that it provides some additional (mostly T-cell) immunity against viral components other than the spike protein which can increase efficacy against severe disease if used in combination with one of the other vaccines.
 
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Samuel said:
are you recovered a bit at least? i hope so.

i was under the impression that you thought it was the spike protein and not the type of vaccine or so. perhaps i was mistaken?
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I was starting to recover from the second Moderna vaccine and then had the Pfizer booster so I'm right back to going through adverse reactions again. Normally I get hit with exhaustion from the vaccines but this time it has left me really tired all day long.

No, it wasn't me who thought that it was the spike protein that was the problem. My understanding is that the vaccine revs up our immune system and that for some reason our immune system doesn't settle back down again to 'normal'.
 
In February, the UK medicines regulator approved the first Covid vaccine based on an older, more established technology. Its developer, Novavax, has pitched it as an alternative for people reluctant to take newer mRNA-based jabs.

But while it is now available in much of Europe, Novavax is still not cleared for use in the UK.

"It's been so frustrating - and it's not just me," says a woman in her 40s, who did not want to be named.
"There are other people out there who are not anti-vax or anything like that, but are just hesitant to take the new kind of mRNA vaccines."

She caught Covid last year and spent five nights in hospital on oxygen. Last month she travelled from the UK to a vaccine clinic in France to have the Novavax jab.

Whatever happened to the Novavax Covid vaccine? - BBC News
 
MeSci said:
In February, the UK medicines regulator approved the first Covid vaccine based on an older, more established technology. Its developer, Novavax, has pitched it as an alternative for people reluctant to take newer mRNA-based jabs.

But while it is now available in much of Europe, Novavax is still not cleared for use in the UK.
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That is strange, it has been available in Australia for a while now as well.
 
MeSci said:
In February, the UK medicines regulator approved the first Covid vaccine based on an older, more established technology. Its developer, Novavax, has pitched it as an alternative for people reluctant to take newer mRNA-based jabs.

But while it is now available in much of Europe, Novavax is still not cleared for use in the UK.
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Novavax was approved for use here in Canada back in February.
 
Paywalled opinion piece in Swedish newspaper DN today, written by a psychologist.

Insändare. ”Lyssna på oss som drabbats av vaccinets biverkningar”
https://www.dn.se/insandare/lyssna-pa-oss-som-drabbats-av-vaccinets-biverkningar/
Auto-translate said:
"Listen to those of us affected by the side effects of the vaccine"

Since 14 May last year, my body has been burning. A fiery nerve pain, like a thousand needles, in my arms, legs, torso, face and chest has lowered my quality of life and left a deep mark on my daily life. I have felt so alone, because no one has really wanted to listen when I say that I am convinced that the symptoms are a side effect of the vaccine against covid-19. It has felt like swearing in church, a violation of a common, silent agreement not to criticize anything sacred.

After six months, I finally found some others who could confirm my experience. About 20 people, now up to 37, testified in a closed Facebook group to exactly the same kind of symptoms: numbness, tingling, a feeling of fire in the body, tinnitus, all linked to the time of vaccination, often immediately after injection.

We had identical experiences of not being taken seriously, of not being seen by the health care system, politicians or the media. Rejected referrals, doctors failing to report to the Medical Products Agency, rejection after rejection of Medicines Insurance claims, belittlement of us as individuals - all of these have contributed to making life even more desperate.

We were in favour of the vaccination programme and wanted to protect both ourselves and society, but when we drew the shortest straw in the vaccine lottery, we were left in the lurch. [...]
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About 20 people, now up to 37, testified in a closed Facebook group to exactly the same kind of symptoms: numbness, tingling, a feeling of fire in the body, tinnitus, all linked to the time of vaccination, often immediately after injection.

For a population of ten million you would expect at least 37 to have these symptoms starting at any chosen time you like. And starting immediately after injection would be against a reaction to the vaccine itself.

Everyone deserves sympathy for being ill but 'being left in the lurch' seems an unreasonable charge.
 
Jonathan Edwards said:
About 20 people, now up to 37, testified in a closed Facebook group to exactly the same kind of symptoms: numbness, tingling, a feeling of fire in the body, tinnitus, all linked to the time of vaccination, often immediately after injection.

For a population of ten million you would expect at least 37 to have these symptoms starting at any chosen time you like. And starting immediately after injection would be against a reaction to the vaccine itself.

Everyone deserves sympathy for being ill but 'being left in the lurch' seems an unreasonable charge.
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The adverse reactions to the covid vaccine don't always happen immediately after the vaccine, but can be a delayed reaction sometimes starting weeks after the vaccine. That has been confirmed to me by a researcher working on a vaccine study here in Canada that I participated in.

I've always had mild ME symptoms until having the Moderna vaccines. My symptoms are now severe. I never had neuropathy before the vaccines. I never had problems with walking before the vaccines. I've met people online who have gone from healthy working individuals to bedridden since having the vaccine. People are reporting online that their Neurologists and Immunologists are saying that in the past year over 50% of their new patients are all complaining of the same symptoms, all having started within weeks of getting the covid vaccine.

Just like people not believing that ME is a real medical issue, there are doctors who don't want to believe that people are having these experiences caused by a vaccine. Seriously, I had mild ME for 30 years and five days after having the first vaccine it is just a coincidence that my ME suddenly gets severe????????????? It's just a coincidence that a week after having the second vaccine that I have neuropathy???????? That's BS.
 
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TigerLilea said:
Just like people not believing that ME is a real medical issue,
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Believing that people have the symptoms they have is a completely different thing from accepting causal explanations based on individual cases that can never be proven.

Coincidences occur all the time. The only way to establish that there is a causal link is to do large systematic studies.

TigerLilea said:
The adverse reactions to the covid vaccine don't always happen immediately after the vaccine, but can be a delayed reaction sometimes starting weeks after the vaccine.
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Yes, I was making the point that if an event like generalised tingling and numbness occurs immediately after the vaccine it is pretty unlikely to be an adverse reaction to vaccine. If there is an adverse immune reaction it is likely to take much longer.
 
I seem to recall that, in the initial vaccine trial, a small number of people reported side effects --- when they unblinded the trial they found that there was a higher number in the placebo group (saline injection?) compared to the group which was vaccinated.
 
A Swedish humour/documentary show on public service TV, 18 minutes long.

Skav: Soten och boten
https://www.svtplay.se/video/35061351/skav/skav-soten-och-boten-soten-och-boten
Auto-translate said:
Comedian Christoffer Nyqvist's life was good and his career was flourishing, when suddenly everything fell apart. Christoffer is one of more than 300 young, fit men who suffered serious heart problems after the covid vaccination. Was it stupid to vaccinate? Or nice to take a bullet for grandma? Christoffer's thoughts are delivered in smoking hot standup and interviews with, among others, vaccine opponent Ulf Bejerstrand and former state epidemiologist Anders Tegnell.
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Moved post

Objectives: Acute necrotizing encephalopathy (ANE) is a rare neurological disorder arising from a para- or post-infectious “cytokine storm. ”It has recently been reported in association with coronavirus disease 2019 (COVID-19) infection.

Methods: A 56-year-old male with a diagnosis of ANE 48 h following the first dose of ChAdOx1 nCoV-19 vaccination was investigated. Cytokine analyses on serum and cerebrospinal fluid (CSF) were performed. The patient was treated with high-dose corticosteroids and followed clinically and radiologically.

Results: Favorable clinical and radiological outcomes were noted. There was an upregulation in serum levels of CXCL5, CXCL1, Il-8, IL-15, CCL2, TGF-B, and EGF, and up-regulation in CSF levels of CXCL5, IL-2, IL-3, and IL-8.

Discussion: As COVID-19 infection has been previously reported as a possible rare cause of ANE, we speculate on an aberrant immune response mechanism that was brought about by the vaccine. To increase our understanding of the pathogenesis of ANE in the context of COVID-19 vaccination and to better define its clinical features and outcomes, clinicians and scientists should continue reporting convincing cases of such entities.
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https://www.frontiersin.org/article...ET&utm_campaign=ECO_FNEUR_XXXXXXXX_auto-dlvri
 
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moved post

https://www.sciencedirect.com/science/article/pii/S0929664621005957#fig1

Husband with ME diagnosed in 2006 but ill for years before.

2 weeks ago he developed a bad rash but declined getting it looked at (.....you know how men can be....!). I thought it looked like potentially a viral rash....
Phoned 111 yesterday, who I must say were very good and responsive and referred locally to out of hours doctor. Appointment, straight in no messing about at 4.30[m.

Diagnosed Pityriasis rosea- linked with herpes which he has had badly in last 5 years.

So after others locally had had similar following vaccination, I found this FYI



Journal of the Formosan Medical Association
Volume 121, Issue 5, May 2022, Pages 1003-1007

Case Report
Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review
Author links open overlay panelChii-ShyanWangaHsuan-HsiangChenb
Shih-HaoLiuc
a
Department of Dermatology, En Chu Kong Hospital, New Taipei City, Taiwan
b
Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
c
Department of Pathology, En Chu Kong Hospital, New Taipei City, Taiwan
Received 15 September 2021, Revised 20 October 2021, Accepted 28 December 2021, Available online 5 January 2022, Version of Record 22 April 2022.
 
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On my facebook page has arrived a link to a UK group for those with vaccine injuries. They already seem to be in touch with a firm of solicitors with a view to investigating legal action.

Many of the grievances are around lack of or poor medical care even when diseases such as guillain barre are eventually diagnosed.
 
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"One group of people where I think that is particularly the case is people who have developed long Covid-type symptoms after having the Covid vaccine," Dr Deans added.

"While the Covid vaccine has saved lots of lives and at population level has been a good thing, we're now uncovering evidence that some people are developing this same kind of presentation - long Covid - after the vaccine, and it seems that has triggered it."

https://www.bbc.co.uk/news/uk-scotland-north-east-orkney-shetland-61617044

Even mentions autoimmunity, mast cell activation & micro-clotting!
 
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From the Daily Telegraph

AstraZeneca vaccine may increase risk of serious neurological condition

Scientists believe the jab’s Trojan horse delivery system could be causing a rise in Guillain-Barré syndrome cases

BySarah Knapton, SCIENCE EDITOR28 May 2022 • 5:26pm

The AstraZeneca vaccine may increase the risk of the serious neurological condition Guillain-Barré syndrome (GBS) with the jab’s Trojan horse delivery system possibly to blame, scientists believe, in a discovery which may apply to similar vaccines.
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Like many vaccines, the Oxford jab uses a weakened chimp adenovirus to deliver the coronavirus spike protein into the body, and scientists have speculated that a reaction to adenovirus may be responsible for the rise in cases.

.................

"'The EMA and other international bodies including the WHO, have all stated that the benefits of vaccination continue to outweigh any potential risks.”
 
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