Covid-19 vaccines and vaccinations

Aren't many of us forum members in some way conspiracists? And EBM hasn't always been good to us, or reliable. I think that's where the merits of discussion come in.

 

Who said anything about inventing anything?

I fail to see how "conspiracy" hasn't devolved into a sad and twisted cliche any more than EBM.

Again, I'd let the discussions carry themselves where they will. It's a forum. Once we pre-emptively begin deciding what is truth or not, I fear it becomes a little less. You talk about evidence, but I think much of what is bantered around as evidence sometimes is only someones perspective or position - and this includes far too many studies - bolstered with rhetoric.

We all thrive on evidence and facts. That's why we're here. But discussion helps sift through the nonsense, and by nonsense, you can pick your poison.

 

Additive effects of booster mRNA vaccination and SARS-CoV-2 Omicron infection on T cell immunity across immunocompromised states

Abstract
Suboptimal immunity to SARS-CoV-2 mRNA vaccination has frequently been observed in individuals with various immunodeficiencies. Given the increased antibody evasion properties of emerging SARS-CoV-2 subvariants, it is necessary to assess whether other components of adaptive immunity generate resilient and protective responses against infection. We assessed T cell responses in 279 individuals, covering five different immunodeficiencies and healthy controls, before and after booster mRNA vaccination, as well as after Omicron infection in a subset of patients.

We observed robust and persistent Omicron-reactive T cell responses that increased markedly upon booster vaccination and correlated directly with antibody titers across all patient groups. Poor vaccination responsiveness in immunocompromised or elderly individuals was effectively counteracted by the administration of additional vaccine doses. Functionally, Omicron-reactive T cell responses exhibited a pronounced cytotoxic profile and signs of longevity, characterized by CD45RA+ effector memory subpopulations with stem cell–like properties and increased proliferative capacity.

Regardless of underlying immunodeficiency, booster-vaccinated and Omicron-infected individuals appeared protected against severe disease and exhibited enhanced and diversified T cell responses against conserved and Omicron-specific epitopes.

Our findings indicate that T cells retain the ability to generate highly functional responses against newly emerging variants, even after repeated antigen exposure and a robust immunological imprint from ancestral SARS-CoV-2 mRNA vaccination.

https://www.science.org/doi/10.1126/scitranslmed.adg9452

 

Next Generation Covid Vaccines Update (No 9): Major New Hat in the Ring Plus Important Results

By Hilda Bastian

https://absolutelymaybe.plos.org/20...r-new-hat-in-the-ring-plus-important-results/

(I have not read this yet but I wanted to post it now so I would not forget)

 

"Covid vaccines will not be offered routinely to healthy under-65s this winter, following advice from UK immunisation experts.

Last autumn, all over-50s were invited for a booster jab to protect them during the winter months.

But only the over-65s should get the option this year, the Joint Committee on Vaccination and Immunisation said."

https://www.bbc.co.uk/news/health-66319065

 

I'm under 60, have no known health conditions and got a booster appointment notification this week.
My OH , with health conditions didn't . Very weird .

 

Not registered as one , so who knows ...

 

Or because your GP has logged you as at risk. I wasn't considered at risk for most of the pandemic, but I got the booster in May for that reason, and have been offered ongoing access to LFTs and antivirals if I test positive. I'm in my 60s.

I think I'm on the list because I take an antirheumatic medication that can alter white blood cell levels. It does depress my neutrophil count, but the haematologist says I've never tested low enough for there to be any concerns and they'd immediately take me off it if I did. So who knows what the logic is behind the 'at risk' flag.

 

Thanks Trish

 

Diabetes following SARS-CoV-2 infection: Incidence, persistence, and implications of COVID-19 vaccination. A cohort study of fifteen million people. (2023, Preprint: MedRxiv)

 

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

https://www.biorxiv.org/content/10.1101/2023.08.16.553640v1

 

Gotta love how the whole messaging over the last year has been that it's now completely safe, "back to normal", because everyone is vaccinated and everyone can get treated if they get severely ill. It's the same message everywhere I see. Well, in rich countries anyway. The rest of the world mostly has nothing.

Now at best 10% have a recent vaccination, it won't even be offered to most people when it's out, and treatments are very restricted. Only severe illness is ever mentioned, absolutely nothing about Long Covid, it's completely covered up. And of course to most people, severe illness that gets you to a hospital is very disruptive.

It's truly managed from a PR perspective and nothing else. It's vaporware healthcare. Vaporcare, I guess.

 

In Britain, there's been some talk in the press about Covid jabs possibly being available for sale next year. At the moment they're only provided free by the NHS, but of course only to increasingly restricted groups.

It would be good if it could be offered on the 'flu model. Here, if you don't qualify for the annual NHS 'flu programme, large supermarkets offer jabs for £12 and neighbourhood pharmacies for about £15. I have doubts the Covid vaccine would be anything like as cheap or accessible, though. If it still needs specialised storage or the wholesale cost is relatively high, supermarkets are unlikely to offer it because there'd be questions over the level of demand. It'll more likely be shiny private clinics charging £150 or £200 a go.

 

Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS-CoV-2: Possible molecular mechanisms (2023, PROTEOMICS – Clinical Applications)

 

could you explain what this means in very simple terms?

 

The very short version is they found spike protein (vaccine-specific, not virus) in blood between 69-187 days from vaccination in 50%. (This isn't supposed to happen, but has been demonstrated by other groups).

On the technical side, they describe their technique, using mass spectrometry following trypsinisation, which they say will work for other body fluids (urine, saliva, lung lavage fluid).

They also say they can use this technique to detect vaccine spike in any body tissue - data in preparation.