Hmm, on the idea that 'co-morbidities are central in ME/CFS'. Of course it depends on what you define as a comorbidity, but asthma was mentioned, and I don't think we have seen good evidence for that being central in ME/CFS. Similarly for depression. I think the doctors mentioned who believe that co-morbidities are central probably don't understand ME/CFS very well.
I do like Katherine's approach of taking people reporting IBS in the UK Biobank and comparing various biological measures between e.g. people reporting IBS and ME/CFS in the UK Biobank. That does seem like a good way to identify some potentially important differences. But, to me, that approach is the exact opposite of assuming that co-morbidities are central - it's a way of teasing out the noise in the symptoms that people present with.
The PEM project (predicting PEM from data from wearables and biometric data) sounds good.
I do like Katherine's approach of taking people reporting IBS in the UK Biobank and comparing various biological measures between e.g. people reporting IBS and ME/CFS in the UK Biobank. That does seem like a good way to identify some potentially important differences. But, to me, that approach is the exact opposite of assuming that co-morbidities are central - it's a way of teasing out the noise in the symptoms that people present with.
The PEM project (predicting PEM from data from wearables and biometric data) sounds good.
