multiple sclerosis

  1. J

    A pilot study of oxidative pathways in MS fatigue: randomized trial of N‐acetyl cysteine, Krysko, 2021

    https://onlinelibrary.wiley.com/doi/10.1002/acn3.51325 Interpretation NAC was well‐tolerated in progressive MS, although reduction in fatigue on NAC was similar to placebo. Antioxidant blood and MRS biomarkers were not significantly altered by NAC, which could be due to dose, route of...
  2. W

    Multiple Sclerosis and ME/CFS - similarities, differences, misdiagnoses

    Mod note: we have broadened the scope of this thread which was originally just about the possibility of having both MS and ME/CFS. Is anyone living with both MS and ME and is there any real reason (research based) to believe that you can’t have both? I might have both, the reason for my...
  3. Mij

    Cardiac autonomic function in patients with early multiple sclerosis 2021, Richard Imrich et al

    https://link.springer.com/article/10.1007/s10286-021-00790-w
  4. Kalliope

    Nat Commun - Early-life-trauma triggers interferon-β resistance and neurodegeneration in a MS model via down regulated β1-adrenergic signaling - Khaw

    Nature Communications: Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling - Yee Ming Khaw et al Abstract Environmental triggers have important functions in multiple sclerosis (MS) susceptibility...
  5. rvallee

    Effect of a Tailored Activity Pacing Intervention on Fatigue and Physical Activity Behaviours in Adults with MS, 2020

    Effect of a Tailored Activity Pacing Intervention on Fatigue and Physical Activity Behaviours in Adults with Multiple Sclerosis https://www.mdpi.com/1660-4601/18/1/17/htm Not very relevant to us but always interesting to see how similar studies are run in other diseases. I am not aware if PEM...
  6. Sly Saint

    Relationship between Fatigue and Physical Activity in a Polish Cohort of Multiple Sclerosis Patients : Rzepka et al 2020

    https://www.mdpi.com/1010-660X/56/12/726?type=check_update&version=2
  7. J

    Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis..., 2020, Nourbakhsh et al

    Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30354-9/fulltext
  8. J

    Gut microbiota–specific IgA+ B cells traffic to the CNS in active multiple sclerosis, 2020 Probstel et al.

    https://immunology.sciencemag.org/content/5/53/eabc7191
  9. J

    Bifrontal transcranial direct current stimulation modulates fatigue in multiple sclerosis: a randomized sham-controlled study, Chalah, 2020

    https://link.springer.com/article/10.1007/s00702-020-02166-2
  10. J

    The Role of Ketamine Infusion for Patients with MS-Related Fatigue

    https://www.neurologyadvisor.com/topics/multiple-sclerosis/the-role-of-ketamine-infusion-for-patients-with-ms-related-fatigue/ Primary outcome of the study was negative. Reference Fitzgerald KC, Morris B, Soroosh A, et al. Pilot randomized active-placebo-controlled trial of low-dose ketamine...
  11. Webdog

    Behavioral practices of patients with multiple sclerosis during Covid-19 pandemic, 2020, Alnajashi/Jabbad

    Full text: https://doi.org/10.1371/journal.pone.0241103241103 Study of 176 Multiple Sclerosis (MS) patients in Saudi Arabia. Spacing mine.
  12. Andy

    Immunometabolic profiling of T cells from .. relapsing-remitting [MS] .. impairment in glycolysis and mitochondrial respiration, 2017, Matarese et al

    Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext
  13. Andy

    The Role of Iron Metabolism in Fatigue, Depression, and Quality of Life in Multiple Sclerosis Patients, 2020, Knyszyńska et al

    Note: The term "chronic fatigue syndrome" is used often in this paper. As far as I can see the authors actually mean "chronic fatigue", which is why I have opened this thread in the "Health News and Research unrelated to ME/CFS" sub-forum, not elsewhere. Open access...
  14. J

    Regional microglial activation in the substantia nigra is linked with fatigue in MS, 2020, Singhal et al.

    https://nn.neurology.org/content/7/5/e854 Popular article here Hunting for a "Hidden Pathology": Why Is Fatigue So Debilitating in Multiple Sclerosis? https://www.technologynetworks.com/neuroscience/news/hunting-for-a-hidden-pathology-why-is-fatigue-so-debilitating-in-multiple-sclerosis-339120
  15. Sly Saint

    Fatigue in Multiple Sclerosis Is Associated With Childhood Adversities: Pust et al Aug 2020

    https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00811/full
  16. Andy

    A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome.., 2017, Morris et al

    Full title: A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause? Open access, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842501/
  17. J

    New MS Drug Approved — Ofatumumab is first self-administered, targeted B-cell treatment for relapsing MS

    Another drug for MS, still nothing for MECFS. https://www.medpagetoday.com/neurology/multiplesclerosis/88195
  18. J

    No Benefit of 3 Commonly Used Medications in MS Fatigue

    https://www.medscape.com/viewarticle/931397 might be paywalled
  19. J

    Pilot randomized active-placebo-controlled trial of low-dose ketamine for the treatment of multiple sclerosis–related fatigue, 2020, Fitzgerald et al

    Popular article https://multiplesclerosisnewstoday.com/news-posts/2020/07/07/pilot-randomized-active-placebo-controlled-trial-of-low-dose-ketamine-for-the-treatment-of-multiple-sclerosisrelated-fatigue/ Journal https://journals.sagepub.com/doi/abs/10.1177/1352458520936226?journalCode=msja
  20. Dolphin

    'Holy Grail' discovery could mean 'nobody needs to worry about their MS getting worse' – study

    Continues at: https://www.irishexaminer.com/world/arid-40027451.html Early days yet of course.
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