multiple sclerosis

Anthony Harrison, Reza Safari Tom Mercer, Federica Picariello, Marietta L van der Linden, Claire White, Rona Moss-Morris Sam Norton** Abstract Background: Fatigue is a common, debilitating symptom of multiple sclerosis (MS) without a current standardised treatment. Objective: The aim of...

https://onlinelibrary.wiley.com/doi/10.1002/acn3.51325 Interpretation NAC was well‐tolerated in progressive MS, although reduction in fatigue on NAC was similar to placebo. Antioxidant blood and MRS biomarkers were not significantly altered by NAC, which could be due to dose, route of...

Mod note: we have broadened the scope of this thread which was originally just about the possibility of having both MS and ME/CFS. Is anyone living with both MS and ME and is there any real reason (research based) to believe that you can’t have both? I might have both, the reason for my...

https://link.springer.com/article/10.1007/s10286-021-00790-w

Nature Communications: Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling - Yee Ming Khaw et al Abstract Environmental triggers have important functions in multiple sclerosis (MS) susceptibility...

Effect of a Tailored Activity Pacing Intervention on Fatigue and Physical Activity Behaviours in Adults with Multiple Sclerosis https://www.mdpi.com/1660-4601/18/1/17/htm Not very relevant to us but always interesting to see how similar studies are run in other diseases. I am not aware if PEM...

https://www.mdpi.com/1010-660X/56/12/726?type=check_update&version=2

Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30354-9/fulltext

https://immunology.sciencemag.org/content/5/53/eabc7191

https://link.springer.com/article/10.1007/s00702-020-02166-2

https://www.neurologyadvisor.com/topics/multiple-sclerosis/the-role-of-ketamine-infusion-for-patients-with-ms-related-fatigue/ Primary outcome of the study was negative. Reference Fitzgerald KC, Morris B, Soroosh A, et al. Pilot randomized active-placebo-controlled trial of low-dose ketamine...

Full text: https://doi.org/10.1371/journal.pone.0241103241103 Study of 176 Multiple Sclerosis (MS) patients in Saudi Arabia. Spacing mine.

Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext

Note: The term "chronic fatigue syndrome" is used often in this paper. As far as I can see the authors actually mean "chronic fatigue", which is why I have opened this thread in the "Health News and Research unrelated to ME/CFS" sub-forum, not elsewhere. Open access...

https://nn.neurology.org/content/7/5/e854 Popular article here Hunting for a "Hidden Pathology": Why Is Fatigue So Debilitating in Multiple Sclerosis? https://www.technologynetworks.com/neuroscience/news/hunting-for-a-hidden-pathology-why-is-fatigue-so-debilitating-in-multiple-sclerosis-339120

https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00811/full

Full title: A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause? Open access, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842501/

Another drug for MS, still nothing for MECFS. https://www.medpagetoday.com/neurology/multiplesclerosis/88195

https://www.medscape.com/viewarticle/931397 might be paywalled

Popular article https://multiplesclerosisnewstoday.com/news-posts/2020/07/07/pilot-randomized-active-placebo-controlled-trial-of-low-dose-ketamine-for-the-treatment-of-multiple-sclerosisrelated-fatigue/ Journal https://journals.sagepub.com/doi/abs/10.1177/1352458520936226?journalCode=msja