Effect of a Tailored Activity Pacing Intervention on Fatigue and Physical Activity Behaviours in Adults with Multiple Sclerosis
https://www.mdpi.com/1660-4601/18/1/17/htm
Not very relevant to us but always interesting to see how similar studies are run in other diseases. I am not aware if PEM...
Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(20)30354-9/fulltext
https://www.neurologyadvisor.com/topics/multiple-sclerosis/the-role-of-ketamine-infusion-for-patients-with-ms-related-fatigue/
Primary outcome of the study was negative.
Reference
Fitzgerald KC, Morris B, Soroosh A, et al. Pilot randomized active-placebo-controlled trial of low-dose ketamine...
Full title: Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration
Open access, https://www.metabolismjournal.com/article/S0026-0495(17)30217-2/fulltext
Note: The term "chronic fatigue syndrome" is used often in this paper. As far as I can see the authors actually mean "chronic fatigue", which is why I have opened this thread in the "Health News and Research unrelated to ME/CFS" sub-forum, not elsewhere.
Open access...
https://nn.neurology.org/content/7/5/e854
Popular article here
Hunting for a "Hidden Pathology": Why Is Fatigue So Debilitating in Multiple Sclerosis?
https://www.technologynetworks.com/neuroscience/news/hunting-for-a-hidden-pathology-why-is-fatigue-so-debilitating-in-multiple-sclerosis-339120
Full title: A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?
Open access, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842501/
Popular article
https://multiplesclerosisnewstoday.com/news-posts/2020/07/07/pilot-randomized-active-placebo-controlled-trial-of-low-dose-ketamine-for-the-treatment-of-multiple-sclerosisrelated-fatigue/
Journal
https://journals.sagepub.com/doi/abs/10.1177/1352458520936226?journalCode=msja
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01810-8
https://multiplesclerosisnewstoday.com/blood-factors-impair-metabolism-blood-brain-barrier-ms-study/
I thought this could be of interest, since one of Jarred Younger's upcoming studies is testing the hypothesis...
https://link.springer.com/article/10.1007/s10286-020-00676-3
Autonomic dysfunction, namely gastrointestinal, genitourinary, and cardiovascular abnormalities, is a key feature of the prodromal phase of other neurological disorders, such as Parkinson disease and other synucleinopathies [6]...
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