The micro-clot finding in Long Covid — implications for the possible aetiology of ME/CFS

Going off topic a little.

How the blood is stored can also present different outcomes.

Most researchers observed a significant deterioration in cell deformability after 2 to 3 weeks of storage (see Table 1). At the same time, for several units, the stability of deformability was observed throughout storage (Barshtein et al., 2020b; Islamzada et al., 2020). There was also significant variability in the deformability of the red cells, both between different donors and between PRBC units. In addition, it was found that the preparation of the PRBC unit causes an alteration in the deformability of cells (Barshtein et al., 2020a).

https://www.frontiersin.org/articles/10.3389/fphys.2021.722896/full

 

https://twitter.com/user/status/1536595129171165187

 

https://twitter.com/user/status/1536433302277705729

 

What were the eligibility criteria that determined these treatments for M.E?

 

"full container of clots"? Wouldn't that have killed someone if they had that many clots?

Are they really clots or something else?

 

It doesn't make a lot of sense and I think it is a pity this sort of stuff is going around social media.
Fibrinogen is the normal soluble protein that we all need to be healthy. Clots are the fibrin cleavage product. An apheresis machine designed to remove clots might well give you a pot of fibrin but goodness knows whether there was anything wrong beforehand. The clots are supposed to be microscopic anyway.

 

A UK Professor of Haemostasis and Thrombosis with a short skeptical Twitter thread about microclots causing LC.

 

Doug Kell and Resia Pretorius will be on BBC 4 speaking about their research at 4:30 BST (in just under 1.5 hours from this post). Presumably it will be available afterwards as well.

https://twitter.com/user/status/1557709119494275073

 

A short piece with Kell and Pretorius snips, also someone introducing them who might have been Amy Proal or maybe not. Nothing very new or detailed. Pretorius said she did not think microclots caused symptoms. I think Kell said he thought they did. If they have found them in diabetes and rheumatoid the story is a bit confusing if so.

 

See Persistent capillary rarefication in long COVID syndrome (thread).

 

Transcription of Resia Pretorius's soundbite that Adam posted, for those of you who find reading easier:
(She's talking about ME/CFS)

 

does anyone know how (techinically speaking), i might copy/save that clip that @Adam pwme shared on twitter above, so that i can post it on facebook, please. Goodness there is someone i can tag that i need to hear that statement!

 

I've uploaded it here for you

https://gofile.io/d/zqE84C

 

gosh Adam thats massively helpful, thank you so much!